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Tbio
EPGN
Epigen

Protein Summary
Description
Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332112
  • ENSP00000330375
  • ENSG00000182585
  • ENST00000413830
  • ENSP00000411898
  • ENST00000502358
  • ENSP00000426678
  • ENST00000503098
  • ENSP00000425890
  • ENST00000505212
  • ENSP00000424392
  • ENST00000509145
  • ENSP00000426630
  • ENST00000514968
  • ENSP00000426550

Symbol
  • EPG
  • PRO9904
  • ALGV3072
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.97
biological process
0.78
disease
0.51
cellular component
0.45
gene perturbation
0.44


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.55   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.55   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
1
68.6
balding measurement
1
1
1
64.4
low density lipoprotein cholesterol measurement
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
68.6
balding measurement
1
64.4
low density lipoprotein cholesterol measurement
1
54.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epithelial mitogen
VGNC:2034
461252
Macaque
epithelial mitogen
702632
Mouse
MGI:1919170
71920
Rat
Dog
epithelial mitogen
VGNC:40403
611937
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epithelial mitogen
Macaque
epithelial mitogen
Mouse
Rat
Dog
epithelial mitogen
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6UW88-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Protein-Protein Interactions (27)
1 – 10 of 27
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.923
Data Source:  STRINGDB
BTC
Tbio
Novelty:  0.00673076
Score:  0.859
Data Source:  STRINGDB
AREG
Tchem
Novelty:  0.0017631
Score:  0.833
Data Source:  STRINGDB
HBEGF
Tbio
Novelty:  0.00105355
Score:  0.778
Data Source:  STRINGDB
EGF
Tbio
Novelty:  0.00010809
Score:  0.639
Data Source:  STRINGDB
ERBB4
Tclin
Family:  Kinase
Novelty:  0.00112919
Score:  0.636
Data Source:  STRINGDB
AOX1
Tchem
Family:  Enzyme
Novelty:  0.0025823
Score:  0.63
Data Source:  STRINGDB
NRG4
Tbio
Novelty:  0.02484999
Score:  0.624
Data Source:  STRINGDB
ERBB3
Tclin
Family:  Kinase
Novelty:  0.000868
Score:  0.6
Data Source:  STRINGDB
NRG2
Tbio
Novelty:  0.01986994
Score:  0.59
Data Source:  STRINGDB
Publication Statistics
PubMed Score  60.55

PubMed score by year
PubTator Score  16.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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