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Tbio
PCSK4
Proprotein convertase subtilisin/kexin type 4

Protein Summary
Description
Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed:16040806). May also participate in folliculogenesis in the ovaries (By similarity). This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic proces ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300954
  • ENSP00000300954
  • ENSG00000115257

Symbol
  • PC4
  • PC4
  • SPC5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
histone modification site profile
0.83
kinase perturbation
0.66
tissue sample
0.65
cell type or tissue
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.19   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.19   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Alzheimer disease-amyloid secretase pathway
PathwayCommons: panther
Alzheimer disease-presenilin pathway
Name
Explore in Pharos
Explore in Source
Alzheimer disease-amyloid secretase pathway
Alzheimer disease-presenilin pathway
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (33)
1 – 10 of 33
MBTPS1
Tchem
Family: Enzyme
Novelty: 0.00845881
Score: 0.656
Data Source: STRINGDB
SCG5
Tbio
Novelty: 0.00379377
Score: 0.57
Data Source: STRINGDB
PCSK9
Tclin
Family: Enzyme
Novelty: 0.00030553
Score: 0.56
Data Source: STRINGDB
IZUMO4
Tdark
Novelty: 0.76836026
Score: 0.559
Data Source: STRINGDB
CFD
Tchem
Family: Enzyme
Novelty: 0.00326222
Score: 0.555
Data Source: STRINGDB
IGF2
Tbio
Novelty: 0.00021277
Score: 0.553
Data Source: STRINGDB
FBXO21
Tbio
Novelty: 0.2186203
Score: 0.543
Data Source: STRINGDB
SPCS1
Tbio
Family: Enzyme
Novelty: 0.0731223
Score: 0.534
Data Source: STRINGDB
GPD2
Tbio
Family: Enzyme
Novelty: 0.00951917
Score: 0.531
Data Source: STRINGDB
TSSK6
Tbio
Family: Kinase
Novelty: 0.01684267
Score: 0.519
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.19

PubMed score by year
PubTator Score  116.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer