Tbio CSPG4 Chondroitin sulfate proteoglycan 4

Protein Summary

Description

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q6UVK1
• D3DW77
• Q92675

Gene Name

• CSPG4

Ensembl ID

• ENST00000308508
• ENSP00000312506
• ENSG00000173546

Symbol

• MCSP
• NG2
• MCSP
• MCSPG
• MSK16
• HMW-MAA
• MEL-CSPG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.87
cellular component	0.73
gene perturbation	0.72
cell type or tissue	0.7
tissue	0.62

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.23   (req: < 5)

Gene RIFs: 69   (req: <= 3)

Antibodies: 647   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.23   (req: >= 5)

Gene RIFs: 69   (req: > 3)

Antibodies: 647   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
creatinine measurement	EFO_0004518	1	4	4		73.1
glomerular filtration rate	EFO_0005208	1	4	4		70.9
serum urea measurement	EFO_0009795	1	2	2		49.5
type II diabetes mellitus	EFO_0001360	1	1	0	1.1	38.2
BMI-adjusted hip circumference	EFO_0008039	2	2	3		37.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
creatinine measurement	EFO_0004518	4		73.1
glomerular filtration rate	EFO_0005208	4		70.9
serum urea measurement	EFO_0009795	2		49.5
type II diabetes mellitus	EFO_0001360	0	1.1	38.2
BMI-adjusted hip circumference	EFO_0008039	3		37.3

Reset Zoom  Beta Count   Odds Ratio

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	chondroitin sulfate proteoglycan 4	VGNC:2479	737574
Macaque	chondroitin sulfate proteoglycan 4		713086
Mouse	chondroitin sulfate proteoglycan 4	MGI:2153093	121021
Rat	chondroitin sulfate proteoglycan 4	RGD:619942	81651
Dog	chondroitin sulfate proteoglycan 4		487658

Species	Name	OMA	EggNOG	Inparanoid
Chimp	chondroitin sulfate proteoglycan 4
Macaque	chondroitin sulfate proteoglycan 4
Mouse	chondroitin sulfate proteoglycan 4
Rat	chondroitin sulfate proteoglycan 4
Dog	chondroitin sulfate proteoglycan 4

Protein Structure (0 Structures, 1 AlphaFold Model)

tutorial

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q6UVK1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)

Reactome (18)

PathwayCommons (1)

WikiPathways (1)

A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 18

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Reactome	CS/DS degradation	14 targets	R-HSA-2024101
Reactome	Chondroitin sulfate biosynthesis	20 targets	R-HSA-2022870
Reactome	Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Reactome	Defective B3GALT6 causes EDSP2 and SEMDJL1	20 targets	R-HSA-4420332

Name	Explore in Pharos	Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
CS/DS degradation	14 targets	R-HSA-2024101
Chondroitin sulfate biosynthesis	20 targets	R-HSA-2022870
Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Defective B3GALT6 causes EDSP2 and SEMDJL1	20 targets	R-HSA-4420332

Gene Ontology Terms (22)

Functions (1)

Components (10)

Processes (11)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
protein kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB

Protein-Protein Interactions (107)

Explore Interacting Targets

1 – 10 of 107

• See Interactions on String-DB

LGALS8

Tchem

Novelty:  0.00623836

p_int:  0.999999973

p_ni:  2.2e-8

p_wrong:  5e-9

Data Source:  BioPlex

LGALS3

Tchem

Novelty:  0.00032754

p_int:  0.999999648

p_ni:  3.24e-7

p_wrong:  2.7e-8

Score:  0.63

Data Source:  BioPlex,STRINGDB

LGALS9

Tchem

Novelty:  0.00381766

p_int:  0.999977861

p_ni:  0.000022139

Score:  0.219

Data Source:  BioPlex,STRINGDB

PCBP4

Tbio

Novelty:  0.03763262

p_int:  0.998673224

p_ni:  0.000888796

p_wrong:  0.00043798

Score:  0.337

Data Source:  BioPlex,STRINGDB

HSPG2

Tbio

Family:  Enzyme

Novelty:  0.00159541

Score:  0.968

Data Source:  STRINGDB

NCAN

Tbio

Novelty:  0.00401824

Score:  0.968

Data Source:  STRINGDB

CSPG5

Tbio

Novelty:  0.01629685

Score:  0.967

Data Source:  STRINGDB

BCAN

Tbio

Novelty:  0.00737982

Score:  0.967

Data Source:  STRINGDB

VCAN

Tbio

Novelty:  0.00110986

Score:  0.956

Data Source:  STRINGDB

DCN

Tbio

Novelty:  0.00073027

Score:  0.95

Data Source:  STRINGDB

Publication Statistics

PubMed Score  309.23

PubMed score by year

Reset Zoom

PubTator Score  419.81

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Angiogenesis
Cell membrane
Cell projection
Complete proteome
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Membrane
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
creatinine measurement
glomerular filtration rate
hip circumference
intraocular pressure measurement
serum urea measurement
sex hormone-binding globulin measurement
type II diabetes mellitus
urate measurement

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
cellular phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
nervous system phenotype