You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CSPG4
Chondroitin sulfate proteoglycan 4

Protein Summary
Description
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activatin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308508
  • ENSP00000312506
  • ENSG00000173546

Symbol
  • MCSP
  • NG2
  • MCSP
  • MCSPG
  • MSK16
  • HMW-MAA
  • MEL-CSPG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.87
cellular component
0.73
gene perturbation
0.72
cell type or tissue
0.7
tissue
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.13   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 647   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.13   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 647   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
1.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chondroitin sulfate proteoglycan 4
VGNC:2479
737574
Macaque
chondroitin sulfate proteoglycan 4
713086
Mouse
MGI:2153093
121021
Rat
RGD:619942
81651
Dog
chondroitin sulfate proteoglycan 4
487658
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chondroitin sulfate proteoglycan 4
Macaque
chondroitin sulfate proteoglycan 4
Mouse
Rat
Dog
chondroitin sulfate proteoglycan 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6UVK1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
CS/DS degradation
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
CS/DS degradation
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Gene Ontology Terms (22)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (107)
1 – 10 of 107
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999999973
p_ni: 2.2e-8
p_wrong: 5e-9
Data Source: BioPlex
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.999999648
p_ni: 3.24e-7
p_wrong: 2.7e-8
Score: 0.63
Data Source: BioPlex,STRINGDB
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.999977861
p_ni: 0.000022139
Score: 0.219
Data Source: BioPlex,STRINGDB
PCBP4
Tbio
Novelty: 0.03763262
p_int: 0.998673224
p_ni: 0.000888796
p_wrong: 0.00043798
Score: 0.337
Data Source: BioPlex,STRINGDB
HSPG2
Tbio
Family: Enzyme
Novelty: 0.00159541
Score: 0.968
Data Source: STRINGDB
NCAN
Tbio
Novelty: 0.00401824
Score: 0.968
Data Source: STRINGDB
CSPG5
Tbio
Novelty: 0.01629685
Score: 0.967
Data Source: STRINGDB
BCAN
Tbio
Novelty: 0.00737982
Score: 0.967
Data Source: STRINGDB
VCAN
Tbio
Novelty: 0.00110986
Score: 0.956
Data Source: STRINGDB
DCN
Tbio
Novelty: 0.00073027
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  300.13

PubMed score by year
PubTator Score  419.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: