CSPG4
Chondroitin sulfate proteoglycan 4
Protein Summary
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activatin ...more
- ENST00000308508
- ENSP00000312506
- ENSG00000173546
- MCSP
- NG2
- MCSP
- MCSPG
- MSK16
- HMW-MAA
- MEL-CSPG
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.87 | ||
cellular component | 0.73 | ||
gene perturbation | 0.72 | ||
cell type or tissue | 0.7 | ||
tissue | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 309.23 (req: < 5)
Gene RIFs: 69 (req: <= 3)
Antibodies: 647 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 309.23 (req: >= 5)
Gene RIFs: 69 (req: > 3)
Antibodies: 647 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (107)
LGALS3
Novelty: 0.00032754
p_int: 0.999999648
p_ni: 3.24e-7
p_wrong: 2.7e-8
Score: 0.63
Data Source: BioPlex,STRINGDB
LGALS9
Novelty: 0.00381766
p_int: 0.999977861
p_ni: 0.000022139
Score: 0.219
Data Source: BioPlex,STRINGDB
PCBP4
Novelty: 0.03763262
p_int: 0.998673224
p_ni: 0.000888796
p_wrong: 0.00043798
Score: 0.337
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (20)
Reactome (18)
PathwayCommons (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Reactome | CS/DS degradation | ||||
Reactome | Chondroitin sulfate biosynthesis | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
A tetrasaccharide linker sequence is required for GAG synthesis | ||||
CS/DS degradation | ||||
Chondroitin sulfate biosynthesis | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (1)
Components (10)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
creatinine measurement | 1 | 4 | 4 | 73.1 | |||||
glomerular filtration rate | 1 | 4 | 4 | 70.9 | |||||
serum urea measurement | 1 | 2 | 2 | 49.5 | |||||
1 | 1 | 0 | 1.1 | 38.2 | |||||
BMI-adjusted hip circumference | 2 | 2 | 3 | 37.3 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
creatinine measurement | 4 | 73.1 | |||||
glomerular filtration rate | 4 | 70.9 | |||||
serum urea measurement | 2 | 49.5 | |||||
0 | 1.1 | 38.2 | |||||
BMI-adjusted hip circumference | 3 | 37.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | chondroitin sulfate proteoglycan 4 | VGNC:2479 | 737574 | |||||
Macaque | chondroitin sulfate proteoglycan 4 | 713086 | ||||||
Mouse | MGI:2153093 | 121021 | ||||||
Rat | RGD:619942 | 81651 | ||||||
Dog | chondroitin sulfate proteoglycan 4 | 487658 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | chondroitin sulfate proteoglycan 4 | |||||
Macaque | chondroitin sulfate proteoglycan 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | chondroitin sulfate proteoglycan 4 | |||||
Publication Statistics
PubMed Score 309.23
PubMed score by year
PubTator Score 419.81
PubTator score by year
Related Publications
Text Mined References (87)
GeneRif Annotations (69)
Items per page:
0 of 0
PMID | Year | Title |
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