CSPG4
Chondroitin sulfate proteoglycan 4
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.87 | ||
cellular component | 0.73 | ||
gene perturbation | 0.72 | ||
cell type or tissue | 0.7 | ||
tissue | 0.62 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Reactome | CS/DS degradation | ||||
Reactome | Chondroitin sulfate biosynthesis | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
A tetrasaccharide linker sequence is required for GAG synthesis | ||||
CS/DS degradation | ||||
Chondroitin sulfate biosynthesis | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
creatinine measurement | 1 | 4 | 4 | 73.1 | |||||
glomerular filtration rate | 1 | 4 | 4 | 70.9 | |||||
serum urea measurement | 1 | 2 | 2 | 49.5 | |||||
1 | 1 | 0 | 1.1 | 38.2 | |||||
BMI-adjusted hip circumference | 2 | 2 | 3 | 37.3 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
creatinine measurement | 4 | 73.1 | |||||
glomerular filtration rate | 4 | 70.9 | |||||
serum urea measurement | 2 | 49.5 | |||||
0 | 1.1 | 38.2 | |||||
BMI-adjusted hip circumference | 3 | 37.3 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | chondroitin sulfate proteoglycan 4 | VGNC:2479 | 737574 | |||||
Macaque | chondroitin sulfate proteoglycan 4 | 713086 | ||||||
Mouse | MGI:2153093 | 121021 | ||||||
Rat | RGD:619942 | 81651 | ||||||
Dog | chondroitin sulfate proteoglycan 4 | 487658 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | chondroitin sulfate proteoglycan 4 | |||||
Macaque | chondroitin sulfate proteoglycan 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | chondroitin sulfate proteoglycan 4 | |||||
PMID | Year | Title |
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