Tbio CRTC1 CREB-regulated transcription coactivator 1

Protein Summary

Description

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Uniprot Accession IDs

• Q6UUV9
• A6NMG5
• O75114
• Q6Y3A3
• Q7LDZ2
• Q8IUL3
• Q8IZ34
• Q8IZL1
• Q8N6W3
• Q96AI8
• Q9H801

Gene Name

• CRTC1

Ensembl ID

• ENST00000321949
• ENSP00000323332
• ENSG00000105662
• ENST00000338797
• ENSP00000345001

Symbol

• KIAA0616
• MECT1
• TORC1
• WAMTP1
• MAML2
• MECT1
• Mam-2
• TORC1
• TORC-1
• WAMTP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
biological process	0.76
cell type or tissue	0.72
transcription factor binding site profile	0.66
tissue	0.62

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Creb-related Transcription Factor / Creb-regulated Transcription Coactivator 1

DTO Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Creb-regulated Transcription Coactivator 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.05   (req: < 5)

Gene RIFs: 78   (req: <= 3)

Antibodies: 326   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.05   (req: >= 5)

Gene RIFs: 78   (req: > 3)

Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0