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Tbio
CRTC1
CREB-regulated transcription coactivator 1

Protein Summary
Description
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. (Microbial infectio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321949
  • ENSP00000323332
  • ENSG00000105662
  • ENST00000338797
  • ENSP00000345001

Symbol
  • KIAA0616
  • MECT1
  • TORC1
  • WAMTP1
  • MAML2
  • MECT1
  • Mam-2
  • TORC1
  • TORC-1
  • WAMTP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
biological process
0.76
cell type or tissue
0.72
transcription factor binding site profile
0.66
tissue
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.91   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.91   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
3
6
90.4
Oral ulcer
1
1
0
1.1
73
body height
1
1
1
71.2
growth differentiation factor 15 measurement
1
1
1
67.8
visceral adipose tissue measurement
1
1
1
59.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
90.4
Oral ulcer
0
1.1
73
body height
1
71.2
growth differentiation factor 15 measurement
1
67.8
visceral adipose tissue measurement
1
59.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CREB regulated transcription coactivator 1
VGNC:2379
735806
Macaque
CREB regulated transcription coactivator 1
720274
Mouse
MGI:2142523
382056
Rat
RGD:1589158
684527
Dog
CREB regulated transcription coactivator 1
100684638
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CREB regulated transcription coactivator 1
Macaque
CREB regulated transcription coactivator 1
Mouse
Rat
Dog
CREB regulated transcription coactivator 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6UUV9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Reactome
Transcriptional activation of mitochondrial biogenesis
Name
Explore in Pharos
Explore in Source
Circadian Clock
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Transcriptional activation of mitochondrial biogenesis
Gene Ontology Terms (23)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (60)
1 – 10 of 60
CREB1
Tbio
Family:  TF
Novelty:  0.00018059
Score:  0.994
Data Source:  Reactome,STRINGDB
PPARGC1A
Tbio
Novelty:  0.0003625
Score:  0.926
Data Source:  STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.925
Data Source:  STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.916
Data Source:  STRINGDB
PER1
Tbio
Novelty:  0.01290576
Score:  0.912
Data Source:  STRINGDB
MAML2
Tbio
Novelty:  0.00836375
Score:  0.895
Data Source:  STRINGDB
CRTC3
Tbio
Novelty:  0.04041516
Score:  0.84
Data Source:  STRINGDB
CRTC2
Tbio
Novelty:  0.01888215
Score:  0.831
Data Source:  STRINGDB
CREM
Tbio
Family:  TF
Novelty:  0.00331358
Score:  0.827
Data Source:  STRINGDB
HCN2
Tclin
Family:  IC
Novelty:  0.02421034
Score:  0.822
Data Source:  STRINGDB
Publication Statistics
PubMed Score  101.91

PubMed score by year
PubTator Score  204.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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