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Tbio
CRTC3
CREB-regulated transcription coactivator 3

Protein Summary
Description
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268184
  • ENSP00000268184
  • ENSG00000140577
  • ENST00000420329
  • ENSP00000416573

Symbol
  • TORC3
  • TORC3
  • TORC-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.81
transcription factor perturbation
0.8
cell type or tissue
0.7
transcription factor binding site profile
0.69
microRNA
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.15   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.15   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
94.5
basophil count
3
2
3
93.6
lymphocyte percentage of leukocytes
2
2
2
92.7
heel bone mineral density
3
3
4
92
basophil percentage of leukocytes
2
1
2
86.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
94.5
basophil count
3
93.6
lymphocyte percentage of leukocytes
2
92.7
heel bone mineral density
4
92
basophil percentage of leukocytes
2
86.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CREB regulated transcription coactivator 3
VGNC:11847
453648
Macaque
CREB regulated transcription coactivator 3
709458
Mouse
MGI:1917711
70461
Rat
RGD:1309666
365297
Dog
CREB regulated transcription coactivator 3
VGNC:53163
488747
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CREB regulated transcription coactivator 3
Macaque
CREB regulated transcription coactivator 3
Mouse
Rat
Dog
CREB regulated transcription coactivator 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6UUV7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Reactome
Transcriptional activation of mitochondrial biogenesis
Name
Explore in Pharos
Explore in Source
Circadian Clock
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Transcriptional activation of mitochondrial biogenesis
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (53)
1 – 10 of 53
KIAA1549
Tbio
Novelty:  0.01224835
p_int:  0.999998843
p_ni:  0.000001157
Data Source:  BioPlex
MAGEA10
Tbio
Novelty:  0.05364393
p_int:  0.99373435
p_ni:  1e-7
p_wrong:  0.00626555
Score:  0.209
Data Source:  BioPlex,STRINGDB
CREB1
Tbio
Family:  TF
Novelty:  0.00018059
Score:  0.973
Data Source:  Reactome,STRINGDB
PPARGC1A
Tbio
Novelty:  0.0003625
Score:  0.948
Data Source:  STRINGDB
CRTC1
Tbio
Novelty:  0.01177834
Score:  0.84
Data Source:  STRINGDB
CRTC2
Tbio
Novelty:  0.01888215
Score:  0.833
Data Source:  STRINGDB
CREM
Tbio
Family:  TF
Novelty:  0.00331358
Score:  0.794
Data Source:  STRINGDB
ATF1
Tchem
Family:  TF
Novelty:  0.01450941
Score:  0.759
Data Source:  STRINGDB
EML5
Tdark
Novelty:  0.29826509
Score:  0.713
Data Source:  STRINGDB
SIK2
Tchem
Family:  Kinase
Novelty:  0.01957886
Score:  0.694
Data Source:  STRINGDB
Publication Statistics
PubMed Score  29.15

PubMed score by year
PubTator Score  18.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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