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Tbio
PLET1
Placenta-expressed transcript 1 protein

Protein Summary
Description
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338832
  • ENSP00000341412
  • ENSG00000188771

Symbol
  • C11orf34
  • C11orf34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.72
tissue sample
0.56
cell line
0.53
transcription factor
0.53
tissue
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.28   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.28   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
LYPD2
Tdark
Novelty:  0.55307434
Score:  0.902
Data Source:  STRINGDB
GPLD1
Tbio
Family:  Enzyme
Novelty:  0.00627091
Score:  0.902
Data Source:  STRINGDB
LYPD3
Tbio
Novelty:  0.03248533
Score:  0.902
Data Source:  STRINGDB
MELTF
Tbio
Novelty:  0.00853228
Score:  0.901
Data Source:  STRINGDB
LY6E
Tbio
Novelty:  0.00758512
Score:  0.901
Data Source:  STRINGDB
LY6H
Tbio
Novelty:  0.10210816
Score:  0.9
Data Source:  STRINGDB
FOLR2
Tchem
Novelty:  0.00751372
Score:  0.9
Data Source:  STRINGDB
NRN1L
Tdark
Novelty:  0.56477474
Score:  0.9
Data Source:  STRINGDB
RECK
Tbio
Novelty:  0.00409224
Score:  0.9
Data Source:  STRINGDB
LYPD6B
Tdark
Novelty:  0.1409054
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
3
4
4
98.8
heel bone mineral density
2
3
3
88.4
blood protein measurement
1
1
1
80.8
interleukin 1 receptor antagonist measurement
1
1
1
80.5
interleukin-1 beta measurement
1
1
1
80.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
4
98.8
heel bone mineral density
3
88.4
blood protein measurement
1
80.8
interleukin 1 receptor antagonist measurement
1
80.5
interleukin-1 beta measurement
1
80.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
placenta expressed transcript 1
VGNC:1046
739047
Mouse
MGI:1923759
76509
Rat
RGD:1359217
363060
Dog
placenta expressed transcript 1
VGNC:49875
102156295
Cow
chromosome 15 open reading frame, human C11orf34
505518
Species
Name
OMA
EggNOG
Inparanoid
Chimp
placenta expressed transcript 1
Mouse
Rat
Dog
placenta expressed transcript 1
Cow
chromosome 15 open reading frame, human C11orf34
Publication Statistics
PubMed Score 10.28
PubMed score by year
PubTator Score 2.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title