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Tbio
SLC4A10
Sodium-driven chloride bicarbonate exchanger

Protein Summary
Description
Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity). This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375514
  • ENSP00000364664
  • ENSG00000144290
  • ENST00000415876
  • ENSP00000395797
  • ENST00000446997
  • ENSP00000393066

Symbol
  • NCBE
  • NCBE
  • NBCn2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
protein domain
0.73
kinase perturbation
0.6
gene perturbation
0.59
cell type or tissue
0.57


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.58   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.58   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
3
4
99.1
cognitive function measurement
3
2
3
98.2
mathematical ability
2
1
2
96.6
smoking status measurement
2
1
2
95.5
smoking initiation
2
2
2
88
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
99.1
cognitive function measurement
3
98.2
mathematical ability
2
96.6
smoking status measurement
2
95.5
smoking initiation
2
88
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 10
VGNC:9061
459688
Macaque
solute carrier family 4 member 10
705263
Mouse
MGI:2150150
94229
Rat
RGD:631407
295645
Dog
solute carrier family 4 member 10
VGNC:46430
478766
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 10
Macaque
solute carrier family 4 member 10
Mouse
Rat
Dog
solute carrier family 4 member 10
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6U841-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Bicarbonate transporters (R-HSA-425381)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bicarbonate transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Bicarbonate transporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Protein-Protein Interactions (44)
1 – 10 of 44
AHCYL1
Tchem
Family: Enzyme
Novelty: 0.02176432
Score: 0.766
Data Source: STRINGDB
TMPRSS15
Tchem
Family: Enzyme
Novelty: 0.00118305
Score: 0.723
Data Source: STRINGDB
GATD1
Tdark
Family: Enzyme
Novelty: 0.40291197
Score: 0.72
Data Source: STRINGDB
OSGEP
Tbio
Family: Enzyme
Novelty: 0.0106198
Score: 0.693
Data Source: STRINGDB
SLC12A2
Tclin
Family: Transporter
Novelty: 0.0012043
Score: 0.669
Data Source: STRINGDB
KCNH7
Tclin
Family: IC
Novelty: 0.09755836
Score: 0.64
Data Source: STRINGDB
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00096678
Score: 0.601
Data Source: STRINGDB
SLC9A5
Tchem
Family: Transporter
Novelty: 0.05361766
Score: 0.585
Data Source: STRINGDB
SLC12A5
Tchem
Family: Transporter
Novelty: 0.0017288
Score: 0.575
Data Source: STRINGDB
AQP1
Tbio
Novelty: 0.00067935
Score: 0.571
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.58

PubMed score by year
PubTator Score  12.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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