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Tbio
OPN5
Opsin-5

Protein Summary
Description
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371211
  • ENSP00000360255
  • ENSG00000124818
  • ENST00000638973
  • ENSP00000491960

Symbol
  • GPR136
  • PGR12
  • TMEM13
  • PGR12
  • GPR136
  • GRP136
  • TMEM13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.62
protein domain
0.58
tissue
0.57
molecular function
0.56
cell line
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.01   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.01   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
GNAT2
Tbio
Novelty:  0.01683655
Score:  0.944
Data Source:  STRINGDB
RGR
Tbio
Family:  GPCR
Novelty:  0.03133861
Score:  0.926
Data Source:  STRINGDB
OPN3
Tbio
Family:  GPCR
Novelty:  0.01675307
Score:  0.925
Data Source:  STRINGDB
RHO
Tbio
Family:  GPCR
Novelty:  0.00012925
Score:  0.922
Data Source:  STRINGDB
GNAT1
Tbio
Novelty:  0.03042002
Score:  0.918
Data Source:  STRINGDB
GNGT2
Tbio
Novelty:  0.0468008
Score:  0.918
Data Source:  STRINGDB
RRH
Tbio
Family:  GPCR
Novelty:  0.02439797
Score:  0.917
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.916
Data Source:  STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
Score:  0.916
Data Source:  STRINGDB
OPN1LW
Tbio
Family:  GPCR
Novelty:  0.00323065
Score:  0.916
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Opsins
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Opsins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
57.8
mathematical ability
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
57.8
mathematical ability
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
opsin 5
VGNC:3602
739707
Macaque
opsin 5
705586
Mouse
MGI:2662912
353344
Rat
RGD:727869
316259
Dog
opsin 5
VGNC:44131
100856777
Species
Name
OMA
EggNOG
Inparanoid
Chimp
opsin 5
Macaque
opsin 5
Mouse
Rat
Dog
opsin 5
Publication Statistics
PubMed Score 36.01
PubMed score by year
PubTator Score 30.51
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title