You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PAQR3
Progestin and adipoQ receptor family member 3

Protein Classes
Protein Summary
Description
Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi. This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395594
  • ENSP00000378959
  • ENSG00000163291
  • ENST00000511594
  • ENSP00000425080
  • ENST00000512733
  • ENSP00000421981
  • ENST00000512760
  • ENSP00000426875
  • ENST00000515853
  • ENSP00000422357

Symbol
  • RKTG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
cell type or tissue
0.72
tissue sample
0.7
biological process
0.67
microRNA
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.19   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.19   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
65.3
reticulocyte measurement
2
1
2
20.5
reticulocyte count
1
1
1
20
mean corpuscular hemoglobin
1
1
1
16.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
65.3
reticulocyte measurement
2
20.5
reticulocyte count
1
20
mean corpuscular hemoglobin
1
16.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
progestin and adipoQ receptor family member 3
VGNC:2065
471193
Macaque
progestin and adipoQ receptor family member 3
697120
Mouse
MGI:2679683
231474
Rat
RGD:1310426
305203
Dog
progestin and adipoQ receptor family member 3
VGNC:44259
487820
Species
Name
OMA
EggNOG
Inparanoid
Chimp
progestin and adipoQ receptor family member 3
Macaque
progestin and adipoQ receptor family member 3
Mouse
Rat
Dog
progestin and adipoQ receptor family member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6TCH7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
MAPK family signaling cascades
Reactome
MAPK1/MAPK3 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
MAPK family signaling cascades
MAPK1/MAPK3 signaling
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (42)
1 – 10 of 42
RAF1
Tclin
Family: Kinase
Novelty: 0.00117121
Score: 0.957
Data Source: Reactome,STRINGDB
ARAF
Tchem
Family: Kinase
Novelty: 0.00432488
Score: 0.91
Data Source: Reactome,STRINGDB
BRAF
Tclin
Family: Kinase
Novelty: 0.00253795
Score: 0.903
Data Source: Reactome,STRINGDB
DUSP19
Tbio
Family: Enzyme
Novelty: 0.13289846
Score: 0.721
Data Source: STRINGDB
TSNAX
Tbio
Novelty: 0.00888891
Score: 0.682
Data Source: STRINGDB
TWIST1
Tbio
Family: TF
Novelty: 0.0013639
Score: 0.654
Data Source: STRINGDB
NUDT16
Tbio
Novelty: 0.06032864
Score: 0.652
Data Source: STRINGDB
MMD2
Tbio
Novelty: 0.07096035
Score: 0.639
Data Source: STRINGDB
PAQR6
Tbio
Novelty: 0.10793454
Score: 0.572
Data Source: STRINGDB
MMD
Tbio
Novelty: 0.02646322
Score: 0.562
Data Source: STRINGDB
Publication Statistics
PubMed Score  42.19

PubMed score by year
PubTator Score  20.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: