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Tbio
PAQR6
Membrane progestin receptor delta

Protein Classes
Protein Summary
Description
Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23763432, PubMed:23161870).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292291
  • ENSP00000292291
  • ENSG00000160781
  • ENST00000335852
  • ENSP00000338330
  • ENST00000356983
  • ENSP00000349474
  • ENST00000368270
  • ENSP00000357253

Symbol
  • PRdelta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
gene perturbation
0.62
tissue
0.58
small molecule perturbation
0.5
PubMedID
0.48


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.1   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.1   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
6.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
6.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
progestin and adipoQ receptor family member 6
VGNC:9383
457389
Macaque
progestin and adipoQ receptor family member 6
718264
Mouse
MGI:1916207
68957
Rat
RGD:1584722
681021
Dog
progestin and adipoQ receptor family member 6
VGNC:54154
100687948
Species
Name
OMA
EggNOG
Inparanoid
Chimp
progestin and adipoQ receptor family member 6
Macaque
progestin and adipoQ receptor family member 6
Mouse
Rat
Dog
progestin and adipoQ receptor family member 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6TCH4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (19)
1 – 10 of 19
PAQR9
Tdark
Novelty: 0.39198507
Score: 0.842
Data Source: STRINGDB
PAQR7
Tbio
Novelty: 0.00870986
Score: 0.762
Data Source: STRINGDB
CCDC190
Tdark
Novelty: 3.31387987
Score: 0.721
Data Source: STRINGDB
PGRMC2
Tbio
Novelty: 0.01069278
Score: 0.63
Data Source: STRINGDB
SOX14
Tbio
Family: TF
Novelty: 0.04081868
Score: 0.599
Data Source: STRINGDB
PGRMC1
Tbio
Novelty: 0.00364386
Score: 0.597
Data Source: STRINGDB
PAQR3
Tbio
Novelty: 0.03782801
Score: 0.572
Data Source: STRINGDB
ADIPOQ
Tbio
Novelty: 0.00011196
Score: 0.56
Data Source: STRINGDB
CYB5D2
Tbio
Novelty: 0.23122479
Score: 0.559
Data Source: STRINGDB
PAQR4
Tdark
Novelty: 0.19162213
Score: 0.553
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.10

PubMed score by year
PubTator Score  3.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer