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Tbio
TSSK4
Testis-specific serine/threonine-protein kinase 4

Protein Summary
Description
Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (PubMed:15964553). Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity). This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287913
  • ENSP00000287913
  • ENSG00000139908
  • ENST00000339917
  • ENSP00000339179
  • ENST00000556621
  • ENSP00000452054
  • ENST00000643387
  • ENSP00000495573
  • ENSG00000285140
  • ENST00000645264
  • ENSP00000496404
  • ENST00000645272
  • ENSP00000496710

Symbol
  • C14orf20
  • STK22E
  • TSSK5
  • TSK4
  • TSK-4
  • TSSK5
  • STK22E
  • C14orf20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.73
tissue sample
0.64
cellular component
0.58
virus perturbation
0.55


Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.16   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.16   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1
1
82.9
telomere length
1
1
1
82.9
platelet count
2
2
2
75
platelet count
2
2
2
75
mean corpuscular volume
2
2
2
62
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
82.9
telomere length
1
82.9
platelet count
2
75
platelet count
2
75
mean corpuscular volume
2
62
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
testis specific serine kinase 4
715578
Mouse
MGI:1918349
71099
Dog
testis specific serine kinase 4
480262
Horse
testis specific serine kinase 4
VGNC:49359
100051378
Cow
testis specific serine kinase 4
VGNC:50063
539477
Species
Name
OMA
EggNOG
Inparanoid
Macaque
testis specific serine kinase 4
Mouse
Dog
testis specific serine kinase 4
Horse
testis specific serine kinase 4
Cow
testis specific serine kinase 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6SA08-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (35)
1 – 10 of 35
CREB1
Tbio
Family:  TF
Novelty:  0.00018059
Score:  0.928
Data Source:  STRINGDB
TSKS
Tbio
Family:  Enzyme
Novelty:  0.0886446
Score:  0.78
Data Source:  STRINGDB
TBC1D21
Tdark
Novelty:  0.45203791
Score:  0.712
Data Source:  STRINGDB
ODF1
Tbio
Novelty:  0.01272872
Score:  0.679
Data Source:  STRINGDB
CEP295NL
Tdark
Novelty:  8.4
Score:  0.642
Data Source:  STRINGDB
KLHL10
Tdark
Novelty:  0.09497583
Score:  0.63
Data Source:  STRINGDB
RXFP2
Tbio
Family:  GPCR
Novelty:  0.00932189
Score:  0.559
Data Source:  STRINGDB
MMEL1
Tchem
Family:  Enzyme
Novelty:  0.02700936
Score:  0.554
Data Source:  STRINGDB
SPATC1
Tdark
Novelty:  0.26477487
Score:  0.519
Data Source:  STRINGDB
SPEF1
Tdark
Novelty:  0.14564815
Score:  0.503
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.16

PubMed score by year
PubTator Score  5.7

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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