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Tdark
ZNF474
Zinc finger protein 474

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296600
  • ENSP00000296600
  • ENSG00000164185
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.64
cell type or tissue
0.48
gene perturbation
0.47
tissue sample
0.45
microRNA
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.65   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.65   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
74.8
intraocular pressure measurement
1
2
2
63.6
white matter hyperintensity measurement
5
2
4
5.1
48.3
1
1
0
1.1
31.4
Keratoconus
1
1
1
31.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
74.8
intraocular pressure measurement
2
63.6
white matter hyperintensity measurement
4
5.1
48.3
0
1.1
31.4
Keratoconus
1
31.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 474
700119
Mouse
MGI:1914008
66758
Rat
Dog
zinc finger protein 474
474655
Horse
zinc finger protein 474 [Source:HGNC Symbol;Acc:HGNC:23245]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 474
Mouse
Rat
Dog
zinc finger protein 474
Horse
zinc finger protein 474 [Source:HGNC Symbol;Acc:HGNC:23245]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6S9Z5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (18)
1 – 10 of 18
ZNF202
Tbio
Family:  TF
Novelty:  0.06306212
Score:  0.702
Data Source:  STRINGDB
SPINK14
Tdark
Family:  Enzyme
Novelty:  1.70859136
Score:  0.524
Data Source:  STRINGDB
ZNF554
Tdark
Family:  TF
Novelty:  1.57478216
Score:  0.511
Data Source:  STRINGDB
ZNF556
Tdark
Family:  TF
Novelty:  3.19575048
Score:  0.508
Data Source:  STRINGDB
ZNF689
Tdark
Family:  TF
Novelty:  1.03726427
Score:  0.491
Data Source:  STRINGDB
FSHR
Tclin
Family:  GPCR
Novelty:  0.00123929
Score:  0.483
Data Source:  STRINGDB
ZNF555
Tdark
Family:  TF
Novelty:  1.65285128
Score:  0.479
Data Source:  STRINGDB
ZNF195
Tdark
Family:  TF
Novelty:  0.23029736
Score:  0.473
Data Source:  STRINGDB
ZBTB32
Tbio
Family:  TF
Novelty:  0.04876778
Score:  0.472
Data Source:  STRINGDB
CCDC112
Tbio
Novelty:  0.04210064
Score:  0.453
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.65

PubMed score by year
PubTator Score  0.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer