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Tbio
WDR74
WD repeat-containing protein 74

Protein Summary
Description
Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit (PubMed:26456651). Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (PubMed:29107693). Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278856
  • ENSP00000278856
  • ENSG00000133316
  • ENST00000311713
  • ENSP00000308931
  • ENST00000525239
  • ENSP00000432119
  • ENST00000529106
  • ENSP00000435726

Symbol
  • NSA1
  • Nsa1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor binding site profile
0.87
transcription factor
0.75
disease perturbation
0.74
histone modification site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.07   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.07   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (253)
1 – 10 of 253
MAK16
Tdark
Novelty:  0.07717917
p_int:  0.999999285
p_ni:  7.15e-7
Score:  0.991
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.999923705
p_ni:  0.000072103
p_wrong:  0.000004192
Data Source:  BioPlex
RPF1
Tdark
Novelty:  3.67047505
p_int:  0.999323968
p_ni:  0.000437501
p_wrong:  0.00023853
Score:  0.995
Data Source:  BioPlex,STRINGDB
CARD8
Tbio
Family:  Enzyme
Novelty:  0.0146799
p_int:  0.99930338
p_ni:  0.000458628
p_wrong:  0.000237992
Score:  0.169
Data Source:  BioPlex,STRINGDB
CCNJL
Tdark
Novelty:  2.86306774
p_int:  0.997895289
p_ni:  0.001972516
p_wrong:  0.000132196
Score:  0.188
Data Source:  BioPlex,STRINGDB
WDR12
Tbio
Novelty:  0.03409059
Score:  0.997
Data Source:  STRINGDB
BOP1
Tbio
Novelty:  0.03512044
Score:  0.993
Data Source:  STRINGDB
EBNA1BP2
Tbio
Novelty:  0.02083466
Score:  0.992
Data Source:  STRINGDB
MRTO4
Tbio
Novelty:  0.06676322
Score:  0.991
Data Source:  STRINGDB
NOP2
Tbio
Family:  Enzyme
Novelty:  0.01664777
Score:  0.99
Data Source:  STRINGDB
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
1
2
0
1
42.2
BMI-adjusted waist-hip ratio
1
2
2
40.4
waist-hip ratio
1
2
2
38.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
0
1
42.2
BMI-adjusted waist-hip ratio
2
40.4
waist-hip ratio
2
38.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
WD repeat domain 74
718460
Mouse
MGI:2147427
107071
Rat
RGD:1582881
690229
Dog
WD repeat domain 74
VGNC:48386
483778
Horse
WD repeat domain 74 [Source:HGNC Symbol;Acc:HGNC:25529]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
WD repeat domain 74
Mouse
Rat
Dog
WD repeat domain 74
Horse
WD repeat domain 74 [Source:HGNC Symbol;Acc:HGNC:25529]
Publication Statistics
PubMed Score 18.07
PubMed score by year
PubTator Score 2.08
PubTator score by year