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Tbio
RICTOR
Rapamycin-insensitive companion of mTOR

Protein Summary
Description
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296782
  • ENSP00000296782
  • ENSG00000164327
  • ENST00000357387
  • ENSP00000349959
  • ENST00000511516
  • ENSP00000423019

Symbol
  • KIAA1999
  • PIA
  • AVO3
  • hAVO3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
biological process
0.93
virus perturbation
0.9
transcription factor binding site profile
0.84
histone modification site profile
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 650.89   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 568   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 650.89   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 568   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (39)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
Constitutive Signaling by AKT1 E17K in Cancer
Reactome
Costimulation by the CD28 family
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Constitutive Signaling by AKT1 E17K in Cancer
Costimulation by the CD28 family
Gene Ontology Terms (26)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (173)
1 – 10 of 173
ABTB2
Tdark
Novelty: 3.6
p_int: 0.999810906
p_ni: 0.000189086
p_wrong: 8e-9
Data Source: BioPlex
SKP2
Tbio
Family: Enzyme
Novelty: 0.00202287
p_int: 0.99956488
p_ni: 0.00043512
p_wrong: 1e-9
Score: 0.311
Data Source: BioPlex,STRINGDB
TSHB
Tbio
Novelty: 0.00212016
p_int: 0.998527851
p_ni: 0.001472148
p_wrong: 1e-9
Data Source: BioPlex
IL17RA
Tclin
Novelty: 0.00599602
p_int: 0.9979418
p_ni: 0.0020582
Data Source: BioPlex
RAPGEF5
Tbio
Novelty: 0.02176235
p_int: 0.987032281
p_ni: 0.012967638
p_wrong: 8.1e-8
Data Source: BioPlex
CDC16
Tbio
Novelty: 0.01336597
p_int: 0.984785723
p_ni: 0.015214255
p_wrong: 2.2e-8
Score: 0.185
Data Source: BioPlex,STRINGDB
EFNA5
Tbio
Novelty: 0.00173565
p_int: 0.977214473
p_ni: 0.022785496
p_wrong: 3.1e-8
Score: 0.223
Data Source: BioPlex,STRINGDB
SDF4
Tbio
Novelty: 0.00130572
p_int: 0.973497984
p_ni: 0.026501994
p_wrong: 2.2e-8
Data Source: BioPlex
AVIL
Tbio
Novelty: 0.01112118
p_int: 0.96419034
p_ni: 0.03580966
Score: 0.166
Data Source: BioPlex,STRINGDB
PROZ
Tbio
Family: Enzyme
Novelty: 0.04928676
p_int: 0.95351909
p_ni: 0.04648091
Data Source: BioPlex
Publication Statistics
PubMed Score  650.89

PubMed score by year
PubTator Score  472.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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