Tbio RICTOR Rapamycin-insensitive companion of mTOR

Protein Summary

Description

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6R327
• B2RNX0
• B7ZMF7
• Q68DT5
• Q86UB7
• Q8N3A0
• Q8NCM6

Gene Name

• RICTOR

Ensembl ID

• ENST00000296782
• ENSP00000296782
• ENSG00000164327
• ENST00000357387
• ENSP00000349959
• ENST00000511516
• ENSP00000423019

Symbol

• KIAA1999
• PIA
• AVO3
• hAVO3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
biological process	0.93
virus perturbation	0.9
transcription factor binding site profile	0.84
histone modification site profile	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.99   (req: < 5)

Gene RIFs: 105   (req: <= 3)

Antibodies: 568   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.99   (req: >= 5)

Gene RIFs: 105   (req: > 3)

Antibodies: 568   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0