Tbio ADGRD1 Adhesion G-protein coupled receptor D1

Protein Summary

Description

Orphan receptor. Signals via G(s)-alpha family of G-proteins (PubMed:22025619, PubMed:22575658). Has protumorigenic function especially in glioblastoma (PubMed:27775701). The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]

Uniprot Accession IDs

• Q6QNK2
• B2CKK9
• B7ZLF7
• Q2M1L3
• Q6ZMQ1
• Q7Z7M2
• Q86SM4

Gene Name

• ADGRD1

Ensembl ID

• ENST00000261654
• ENSP00000261654
• ENSG00000111452
• ENST00000535015
• ENSP00000444425
• ENST00000543617
• ENSP00000438021

Symbol

• GPR133
• PGR25
• PGR25
• GPR133

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.81
protein domain	0.73
phenotype	0.68
tissue sample	0.63
cell type or tissue	0.62

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Adhesion G-protein Coupled Receptor D1

Protein / Defense/immunity Protein / Antibacterial Response Protein / Adhesion G-protein Coupled Receptor D1

Protein / ... / Protease / Adhesion G-protein Coupled Receptor D1

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Adhesion G-protein Coupled Receptor D1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.03   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.03   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0