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Tbio
FIGLA
Factor in the germline alpha

Protein Summary
Description
Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332372
  • ENSP00000333097
  • ENSG00000183733

Symbol
  • BHLHC8
  • POF6
  • BHLHC8
  • FIGALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
cell type or tissue
0.56
PubMedID
0.55
biological process
0.51
cell line
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.43   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.43   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
influenza A (H1N1)
1
1
0
19.4
7.6
1
1
0
1.1
1.9
gut microbiome measurement
1
1
0
5.6
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
influenza A (H1N1)
0
19.4
7.6
0
1.1
1.9
gut microbiome measurement
0
5.6
1.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
folliculogenesis specific bHLH transcription factor
VGNC:255
737605
Macaque
folliculogenesis specific bHLH transcription factor
710606
Mouse
MGI:1349421
26910
Rat
RGD:1564754
500239
Dog
folliculogenesis specific bHLH transcription factor
VGNC:54149
100687488
Species
Name
OMA
EggNOG
Inparanoid
Chimp
folliculogenesis specific bHLH transcription factor
Macaque
folliculogenesis specific bHLH transcription factor
Mouse
Rat
Dog
folliculogenesis specific bHLH transcription factor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6QHK4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (55)
1 – 10 of 55
NOBOX
Tbio
Family:  TF
Novelty:  0.01217542
Score:  0.881
Data Source:  STRINGDB
LHX8
Tbio
Family:  TF
Novelty:  0.01815234
Score:  0.862
Data Source:  STRINGDB
BMP15
Tbio
Novelty:  0.00364888
Score:  0.813
Data Source:  STRINGDB
ZP3
Tbio
Novelty:  0.00140352
Score:  0.812
Data Source:  STRINGDB
SOHLH1
Tbio
Family:  TF
Novelty:  0.04218087
Score:  0.804
Data Source:  STRINGDB
GDF9
Tbio
Novelty:  0.00258351
Score:  0.789
Data Source:  STRINGDB
TCF23
Tbio
Family:  TF
Novelty:  0.14221901
Score:  0.78
Data Source:  STRINGDB
ZP2
Tbio
Novelty:  0.00310166
Score:  0.774
Data Source:  STRINGDB
YBX2
Tbio
Family:  TF
Novelty:  0.01540247
Score:  0.756
Data Source:  STRINGDB
POF1B
Tbio
Novelty:  0.1232792
Score:  0.748
Data Source:  STRINGDB
Publication Statistics
PubMed Score  44.43

PubMed score by year
PubTator Score  1.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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