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Tbio
APOA5
Apolipoprotein A-V

Protein Summary
Description
Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromoso ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227665
  • ENSP00000227665
  • ENSG00000110243
  • ENST00000542499
  • ENSP00000445002

Symbol
  • RAP3
  • RAP3
  • APOAV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
biological process
0.98
biological term
0.98
molecular function
0.98
trait
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 508.87   (req: < 5)
Gene RIFs: 314   (req: <= 3)
Antibodies: 686   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 508.87   (req: >= 5)
Gene RIFs: 314   (req: > 3)
Antibodies: 686   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
20
10
42
13.1
99.9
high density lipoprotein cholesterol measurement
13
7
26
2
99.5
total cholesterol measurement
7
6
11
3.8
99.3
low density lipoprotein cholesterol measurement
2
2
2
92.7
metabolic syndrome
4
3
2
1.3
91.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
42
13.1
99.9
high density lipoprotein cholesterol measurement
26
2
99.5
total cholesterol measurement
11
3.8
99.3
low density lipoprotein cholesterol measurement
2
92.7
metabolic syndrome
2
1.3
91.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein A5
VGNC:10230
466791
Mouse
MGI:1913363
66113
Rat
RGD:70903
140638
Dog
apolipoprotein A5
VGNC:37993
489393
Horse
apolipoprotein A5
VGNC:15415
100071101
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein A5
Mouse
Rat
Dog
apolipoprotein A5
Horse
apolipoprotein A5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6Q788-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Chylomicron remodeling
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
Chylomicron remodeling
Metabolism
Metabolism of lipids
Metabolism of proteins
Gene Ontology Terms (48)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (234)
1 – 10 of 234
APOC3
Tclin
Novelty: 0.0009635
Score: 0.991
Data Source: STRINGDB
GPIHBP1
Tbio
Novelty: 0.01241227
Score: 0.988
Data Source: STRINGDB
LPL
Tchem
Family: Enzyme
Novelty: 0.00057058
Score: 0.982
Data Source: STRINGDB
APOB
Tchem
Novelty: 0.00008247
Score: 0.981
Data Source: STRINGDB
APOC2
Tbio
Novelty: 0.0015496
Score: 0.98
Data Source: STRINGDB
CREB3L3
Tbio
Family: TF
Novelty: 0.02519904
Score: 0.973
Data Source: STRINGDB
APOE
Tbio
Novelty: 0.00005049
Score: 0.97
Data Source: STRINGDB
SERPINC1
Tclin
Novelty: 0.00008721
Score: 0.97
Data Source: STRINGDB
APOA2
Tbio
Novelty: 0.00117627
Score: 0.969
Data Source: STRINGDB
PPARA
Tclin
Family: NR
Novelty: 0.00017403
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  508.87

PubMed score by year
PubTator Score  402.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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