Tdark SLC2A7 Solute carrier family 2, facilitated glucose transporter member 7

Protein Summary

Description

High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose. SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Li et al., 2004). This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6PXP3
• A2A333

Gene Name

• SLC2A7

Ensembl ID

• ENST00000400906
• ENSP00000383698
• ENSG00000197241

Symbol

• GLUT7
• GLUT7
• GLUT-7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.58
cell type or tissue	0.56
tissue	0.45
chemical	0.43
tissue sample	0.43

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc2 Family Of Hexose And Sugar Alcohol Transporters / Class Ii Transporters / Solute Carrier Family 2, Facilitated Glucose Transporter Member 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.97   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 20   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.97   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0