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Tbio
CPLX2
Complexin-2

Protein Summary
Description
Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity). Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359546
  • ENSP00000352544
  • ENSG00000145920
  • ENST00000393745
  • ENSP00000377346
  • ENST00000515094
  • ENSP00000421825

Symbol
  • CPX2
  • Hfb1
  • 921-L
  • CPX-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
cellular component
0.83
gene perturbation
0.76
PubMedID
0.68
microRNA
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.85   (req: < 5)
View Publications
Gene RIFs: 11   (req: <= 3)
View Gene RIFs
Antibodies: 158   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.85   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (23)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
SNARE binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
syntaxin-1 binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
calcium-dependent protein binding
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (176)
1 – 10 of 176
CPLX1
Tbio
Novelty: 0.01111396
p_int: 0.999999976
p_ni: 2.4e-8
Score: 0.898
Data Source: BioPlex,STRINGDB
ANKRD13C
Tbio
Novelty: 1.81818182
p_int: 0.99998468
p_ni: 0.000012543
p_wrong: 0.000002777
Score: 0.199
Data Source: BioPlex,STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00466391
p_int: 0.999694768
p_ni: 0.000029472
p_wrong: 0.00027576
Score: 0.228
Data Source: BioPlex,STRINGDB
DEGS1
Tchem
Family: Enzyme
Novelty: 0.00280984
p_int: 0.983074038
p_ni: 0.016925962
Score: 0.188
Data Source: BioPlex,STRINGDB
SCCPDH
Tbio
Family: Enzyme
Novelty: 0.10616502
p_int: 0.907492675
p_ni: 0.092449338
p_wrong: 0.000057987
Score: 0.183
Data Source: BioPlex,STRINGDB
SNAP25
Tclin
Novelty: 0.0020914
Score: 0.966
Data Source: STRINGDB
CPLX4
Tbio
Novelty: 0.06654783
Score: 0.927
Data Source: STRINGDB
VAMP2
Tbio
Novelty: 0.00274235
Score: 0.919
Data Source: STRINGDB
STX1A
Tbio
Novelty: 0.00128938
Score: 0.912
Data Source: STRINGDB
SNAP23
Tbio
Novelty: 0.00732279
Score: 0.885
Data Source: STRINGDB
Publication Statistics
PubMed Score  51.85

PubMed score by year
PubTator Score  49.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer