Pharos : Target Details

Tbio

Protein Summary

Description

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity). Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

Gene Name

CPLX2

Ensembl ID

ENST00000359546
ENSP00000352544
ENSG00000145920
ENST00000393745
ENSP00000377346
ENST00000515094
ENSP00000421825

Symbol

CPX2
Hfb1
921-L
CPX-2

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.83

cellular component	0.83

gene perturbation	0.76

PubMedID	0.68

microRNA	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.52 (req: < 5)

View Publications

Gene RIFs: 11 (req: <= 3)

View Gene RIFs

Antibodies: 158 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.52 (req: >= 5)

Gene RIFs: 11 (req: > 3)

Antibodies: 158 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (176)

Explore Interacting Targets

1 – 10 of 176

See Interactions on String-DB

CPLX1

Tbio

Novelty: 0.01434543

p_int: 0.999999976

p_ni: 2.4e-8

Score: 0.898

Data Source: BioPlex,STRINGDB

ANKRD13C

Tbio

Novelty: 1.5309683

p_int: 0.99998468

p_ni: 0.000012543

p_wrong: 0.000002777

Score: 0.199

Data Source: BioPlex,STRINGDB

RAP1A

Tchem

Family: Enzyme

Novelty: 0.00375413

p_int: 0.999694768

p_ni: 0.000029472

p_wrong: 0.00027576

Score: 0.228

Data Source: BioPlex,STRINGDB

DEGS1

Tchem

Family: Enzyme

Novelty: 0.00300325

p_int: 0.983074038

p_ni: 0.016925962

Score: 0.188

Data Source: BioPlex,STRINGDB

SCCPDH

Tbio

Family: Enzyme

Novelty: 0.06603568

p_int: 0.907492675

p_ni: 0.092449338

p_wrong: 0.000057987

Score: 0.183

Data Source: BioPlex,STRINGDB

SNAP25

Tclin

Novelty: 0.00148905

Score: 0.966

Data Source: STRINGDB

CPLX4

Tdark

Novelty: 0.1755035

Score: 0.927

Data Source: STRINGDB

VAMP2

Tbio

Novelty: 0.00187736

Score: 0.919

Data Source: STRINGDB

STX1A

Tbio

Novelty: 0.00087207

Score: 0.912

Data Source: STRINGDB

SNAP23

Tbio

Novelty: 0.0065371

Score: 0.885

Data Source: STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

KEGG (1)

WikiPathways (1)

Find Similar Targets

Items per page:

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Synaptic vesicle cycle	78 targets	path:hsa04721

Name	Explore in Pharos	Explore in Source
Synaptic vesicle cycle	78 targets	path:hsa04721

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (23)

Functions (3)

Components (11)

Processes (9)

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Items per page:

1 – 3 of 3

GO Term	Evidence	Assigned by
SNARE binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

syntaxin-1 binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

calcium-dependent protein binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword

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No Header	No Header
Coiled coil

Complete proteome

Cytoplasm

Differentiation

Exocytosis

Mast cell degranulation

Neurogenesis

Neurotransmitter transport

Phosphoprotein

Reference proteome

MGI Phenotype

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IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID
Macaque	complexin 2 [Source:HGNC Symbol;Acc:HGNC:2310]

Mouse	complexin 2	MGI:104726	12890

Rat	complexin 2	RGD:70945	116657

Dog	complexin 2	VGNC:39556	489107

Horse	complexin 2	VGNC:16818	100058774

Species	Name	OMA	EggNOG	Inparanoid
Macaque	complexin 2 [Source:HGNC Symbol;Acc:HGNC:2310]

Mouse	complexin 2

Rat	complexin 2

Dog	complexin 2

Horse	complexin 2

Publication Statistics

PubMed Score 53.52

PubMed score by year

PubTator Score 49.16

PubTator score by year

Related Publications

Text Mined References (36)

GeneRif Annotations (11)

Items per page:

0 of 0

PMID	Year	Title