Protein Summary
Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity). Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000359546
- ENSP00000352544
- ENSG00000145920
- ENST00000393745
- ENSP00000377346
- ENST00000515094
- ENSP00000421825
- CPX2
- Hfb1
- 921-L
- CPX-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.83 | ||
cellular component | 0.83 | ||
gene perturbation | 0.76 | ||
PubMedID | 0.68 | ||
microRNA | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.52 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 158 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.52 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 158 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (176)
CPLX1
Novelty: 0.01434543
p_int: 0.999999976
p_ni: 2.4e-8
Score: 0.898
Data Source: BioPlex,STRINGDB
ANKRD13C
Novelty: 1.5309683
p_int: 0.99998468
p_ni: 0.000012543
p_wrong: 0.000002777
Score: 0.199
Data Source: BioPlex,STRINGDB
RAP1A
Family: Enzyme
Novelty: 0.00375413
p_int: 0.999694768
p_ni: 0.000029472
p_wrong: 0.00027576
Score: 0.228
Data Source: BioPlex,STRINGDB
DEGS1
Family: Enzyme
Novelty: 0.00300325
p_int: 0.983074038
p_ni: 0.016925962
Score: 0.188
Data Source: BioPlex,STRINGDB
SCCPDH
Family: Enzyme
Novelty: 0.06603568
p_int: 0.907492675
p_ni: 0.092449338
p_wrong: 0.000057987
Score: 0.183
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
KEGG (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Synaptic vesicle cycle | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Synaptic vesicle cycle | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (3)
Components (11)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | complexin 2 [Source:HGNC Symbol;Acc:HGNC:2310] | |||||||
Mouse | MGI:104726 | 12890 | ||||||
Rat | RGD:70945 | 116657 | ||||||
Dog | complexin 2 | VGNC:39556 | 489107 | |||||
Horse | complexin 2 | VGNC:16818 | 100058774 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | complexin 2 [Source:HGNC Symbol;Acc:HGNC:2310] | |||||
Mouse | ||||||
Rat | ||||||
Dog | complexin 2 | |||||
Horse | complexin 2 | |||||
Publication Statistics
PubMed Score 53.52
PubMed score by year
PubTator Score 49.16
PubTator score by year
Related Publications
Text Mined References (36)
GeneRif Annotations (11)
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