You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
GPR179
Probable G-protein coupled receptor 179

Protein Summary
Description
Orphan receptor, involved in vision. Required for signal transduction through retinal depolarizing bipolar cells. This gene encodes a member of the glutamate receptor subfamily of G protein-coupled receptors. The encoded protein has an EGF-like calcium binding domain and a seven transmembrane domain in the N-terminal region of the protein. Mutations in this gene are associated with congenital stationary night blindness type 1E. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610650
  • ENSP00000484951
  • ENSG00000276469

Symbol
  • GPR158L
  • GPR158L1
  • CSNB1E
  • GPR158L
  • GPR158L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.69
cell line
0.68
disease
0.47
protein complex
0.4
cellular component
0.38


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.56   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.56   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (32)
1 – 10 of 32
LRIT3
Tbio
Novelty: 0.2385612
Score: 0.819
Data Source: STRINGDB
TRPM1
Tchem
Family: IC
Novelty: 0.00822899
Score: 0.775
Data Source: STRINGDB
NYX
Tbio
Novelty: 0.0100148
Score: 0.757
Data Source: STRINGDB
RGS11
Tbio
Novelty: 0.02181028
Score: 0.747
Data Source: STRINGDB
GRM6
Tchem
Family: GPCR
Novelty: 0.00681104
Score: 0.718
Data Source: STRINGDB
RGS7
Tbio
Novelty: 0.01643407
Score: 0.707
Data Source: STRINGDB
CABP4
Tbio
Novelty: 0.04472327
Score: 0.698
Data Source: STRINGDB
GPRC6A
Tchem
Family: GPCR
Novelty: 0.01625616
Score: 0.637
Data Source: STRINGDB
CACNA1F
Tchem
Family: IC
Novelty: 0.00431963
Score: 0.636
Data Source: STRINGDB
SLC24A1
Tbio
Family: Transporter
Novelty: 0.01024169
Score: 0.593
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.56

PubMed score by year
PubTator Score  4.24

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer