Tbio GPR179 Probable G-protein coupled receptor 179

Protein Summary

Description

Orphan receptor, involved in vision. Required for signal transduction through retinal depolarizing bipolar cells. This gene encodes a member of the glutamate receptor subfamily of G protein-coupled receptors. The encoded protein has an EGF-like calcium binding domain and a seven transmembrane domain in the N-terminal region of the protein. Mutations in this gene are associated with congenital stationary night blindness type 1E. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• Q6PRD1

Gene Name

• GPR179

Ensembl ID

• ENST00000610650
• ENSP00000484951
• ENSG00000276469

Symbol

• GPR158L
• GPR158L1
• CSNB1E
• GPR158L
• GPR158L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.69
cell line	0.68
disease	0.47
protein complex	0.4
cellular component	0.38

Protein Classes

PANTHER Classes

Protein / Transporter / Probable G-protein Coupled Receptor 179

DTO Classes

Protein / G-protein Coupled Receptor / Class C Metabotropic Glutamate/pheromone / Probable G-protein Coupled Receptor 179

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.61   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.61   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0