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Tchem
ATAD2
ATPase family AAA domain-containing protein 2

Protein Summary
Description
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287394
  • ENSP00000287394
  • ENSG00000156802

Symbol
  • ANCCA
  • CT137
  • PRO2000
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
molecular function
0.95
protein domain
0.85
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.06   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.06   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (44)
CHEMBL4449894
Rendered image for CHEMBL4449894
CHEMBL3590408
Rendered image for CHEMBL3590408
CHEMBL3590405
Rendered image for CHEMBL3590405
GSK8814
Rendered image for GSK8814
CHEMBL3590391
Rendered image for CHEMBL3590391
CHEMBL4583297
Rendered image for CHEMBL4583297
CHEMBL4576280
Rendered image for CHEMBL4576280
CHEMBL4589592
Rendered image for CHEMBL4589592
CHEMBL4565203
Rendered image for CHEMBL4565203
CHEMBL4521850
Rendered image for CHEMBL4521850
Protein-Protein Interactions (188)
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.954
Data Source:  Reactome,STRINGDB
TFAP2A
Tbio
Family:  TF
Novelty:  0.00235655
Score:  0.903
Data Source:  STRINGDB
TFAP2C
Tbio
Family:  TF
Novelty:  0.00893737
Score:  0.9
Data Source:  STRINGDB
TOP2A
Tclin
Family:  Enzyme
Novelty:  0.00122788
Score:  0.879
Data Source:  STRINGDB
KIF11
Tchem
Novelty:  0.00170673
Score:  0.836
Data Source:  STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
Score:  0.824
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.821
Data Source:  STRINGDB
RRM2
Tclin
Family:  Enzyme
Novelty:  0.00112948
Score:  0.818
Data Source:  STRINGDB
ASPM
Tbio
Novelty:  0.00599688
Score:  0.811
Data Source:  STRINGDB
MAD2L1
Tbio
Novelty:  0.01623659
Score:  0.809
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

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1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Reactome
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
15.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase family, AAA domain containing 2
VGNC:10212
464369
Macaque
ATPase family, AAA domain containing 2
704478
Mouse
MGI:1917722
70472
Rat
RGD:1304849
314993
Dog
ATPase family, AAA domain containing 2
VGNC:38201
475090
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase family, AAA domain containing 2
Macaque
ATPase family, AAA domain containing 2
Mouse
Rat
Dog
ATPase family, AAA domain containing 2
Publication Statistics
PubMed Score 110.06
PubMed score by year
PubTator Score 80.12
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title