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Tchem
ATAD2
ATPase family AAA domain-containing protein 2

Protein Summary
Description
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287394
  • ENSP00000287394
  • ENSG00000156802

Symbol
  • ANCCA
  • CT137
  • PRO2000
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
molecular function
0.95
protein domain
0.85
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.79   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.79   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (18)
1 – 10 of 18
CHEMBL3590408
chemical structure image
CHEMBL3590405
chemical structure image
CHEMBL3590391
chemical structure image
GSK8814
chemical structure image
CHEMBL3590386
chemical structure image
CHEMBL3590396
chemical structure image
CHEMBL3585459
chemical structure image
CHEMBL3590389
chemical structure image
CHEMBL3590382
chemical structure image
CHEMBL3590384
chemical structure image
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase family, AAA domain containing 2
VGNC:10212
464369
Macaque
ATPase family, AAA domain containing 2
704478
Mouse
MGI:1917722
70472
Rat
RGD:1304849
314993
Dog
ATPase family, AAA domain containing 2
VGNC:38201
475090
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase family, AAA domain containing 2
Macaque
ATPase family, AAA domain containing 2
Mouse
Rat
Dog
ATPase family, AAA domain containing 2
Protein Structure (35 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6PL18-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 35
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Reactome
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (188)
1 – 10 of 188
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.954
Data Source: Reactome,STRINGDB
TFAP2A
Tbio
Family: TF
Novelty: 0.00235655
Score: 0.903
Data Source: STRINGDB
TFAP2C
Tbio
Family: TF
Novelty: 0.00893737
Score: 0.9
Data Source: STRINGDB
TOP2A
Tclin
Family: Enzyme
Novelty: 0.00122788
Score: 0.879
Data Source: STRINGDB
KIF11
Tchem
Novelty: 0.00170673
Score: 0.836
Data Source: STRINGDB
CCNA2
Tchem
Novelty: 0.00049887
Score: 0.824
Data Source: STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.821
Data Source: STRINGDB
RRM2
Tclin
Family: Enzyme
Novelty: 0.00112948
Score: 0.818
Data Source: STRINGDB
ASPM
Tbio
Novelty: 0.00599688
Score: 0.811
Data Source: STRINGDB
MAD2L1
Tbio
Novelty: 0.01623659
Score: 0.809
Data Source: STRINGDB
Publication Statistics
PubMed Score  104.79

PubMed score by year
PubTator Score  80.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer