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Tbio
DCLRE1A
DNA cross-link repair 1A protein

Protein Summary
Description
May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361384
  • ENSP00000355185
  • ENSG00000198924
  • ENST00000369305
  • ENSP00000358311

Symbol
  • KIAA0086
  • SNM1
  • SNM1A
  • PSO2
  • SNM1
  • SNM1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
histone modification site profile
0.66
tissue sample
0.66
transcription factor binding site profile
0.64
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.01   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.01   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (312)
1 – 5 of 312
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CACAO
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (137)
1 – 10 of 137
MUS81
Tbio
Family: Enzyme
Novelty: 0.0066722
Score: 0.981
Data Source: STRINGDB
FANCM
Tbio
Novelty: 0.01500746
Score: 0.974
Data Source: STRINGDB
EME1
Tbio
Family: Enzyme
Novelty: 0.01588572
Score: 0.973
Data Source: STRINGDB
SLX4
Tbio
Family: Enzyme
Novelty: 0.01974743
Score: 0.972
Data Source: STRINGDB
ERCC1
Tbio
Novelty: 0.00089943
Score: 0.967
Data Source: STRINGDB
FAN1
Tbio
Family: Enzyme
Novelty: 0.02864548
Score: 0.966
Data Source: STRINGDB
FANCD2
Tbio
Novelty: 0.00341443
Score: 0.963
Data Source: STRINGDB
FANCI
Tbio
Novelty: 0.01680302
Score: 0.961
Data Source: STRINGDB
ERCC4
Tbio
Family: Enzyme
Novelty: 0.01444679
Score: 0.961
Data Source: STRINGDB
FAAP24
Tbio
Novelty: 0.14588123
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  94.01

PubMed score by year
PubTator Score  45.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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