Tbio DCLRE1A DNA cross-link repair 1A protein

Protein Summary

Description

May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• Q6PJP8
• D3DRC1
• Q14701
• Q6P5Y3
• Q6PKL4

Gene Name

• DCLRE1A

Ensembl ID

• ENST00000361384
• ENSP00000355185
• ENSG00000198924
• ENST00000369305
• ENSP00000358311

Symbol

• KIAA0086
• SNM1
• SNM1A
• PSO2
• SNM1
• SNM1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.84
histone modification site profile	0.66
tissue sample	0.66
transcription factor binding site profile	0.64
transcription factor perturbation	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.44   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 104   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.44   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0