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Tbio
BRAT1
BRCA1-associated ATM activator 1

Protein Summary
Description
Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regula ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340611
  • ENSP00000339637
  • ENSG00000106009

Symbol
  • BAAT1
  • C7orf27
  • BAAT1
  • RMFSL
  • NEDCAS
  • C7orf27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.73
cell line
0.65
cell type or tissue
0.61
microRNA
0.59
histone modification site profile
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.53   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.53   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
2
2
62.5
hematocrit
2
2
2
62
mean platelet volume
2
1
2
57.3
reticulocyte measurement
3
2
3
56.6
diastolic blood pressure
1
1
1
11.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
62.5
hematocrit
2
62
mean platelet volume
2
57.3
reticulocyte measurement
3
56.6
diastolic blood pressure
1
11.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BRCA1 associated ATM activator 1
VGNC:7351
463228
Macaque
BRCA1 associated ATM activator 1
699605
Mouse
MGI:1891679
231841
Rat
RGD:1565146
498150
Dog
BRCA1 associated ATM activator 1 [Source:HGNC Symbol;Acc:HGNC:21701]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BRCA1 associated ATM activator 1
Macaque
BRCA1 associated ATM activator 1
Mouse
Rat
Dog
BRCA1 associated ATM activator 1 [Source:HGNC Symbol;Acc:HGNC:21701]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6PJG6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (44)
1 – 10 of 44
PSMD7
Tbio
Family:  Enzyme
Novelty:  0.03090292
p_int:  0.999546487
p_ni:  0.000453513
Data Source:  BioPlex
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.995213743
p_ni:  0.004786256
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.990660294
p_ni:  0.009339706
Data Source:  BioPlex
FXYD6
Tbio
Family:  IC
Novelty:  0.0503209
p_int:  0.975670539
p_ni:  0.024329461
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.940335033
p_ni:  0.059664967
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.934410178
p_ni:  0.065589821
Data Source:  BioPlex
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.906341844
p_ni:  0.093658156
Data Source:  BioPlex
P2RX5
Tchem
Family:  IC
Novelty:  0.01591178
p_int:  0.882390398
p_ni:  0.117609602
Data Source:  BioPlex
TMEM108
Tbio
Novelty:  0.08687599
p_int:  0.86615439
p_ni:  0.133845502
p_wrong:  1.08e-7
Score:  0.181
Data Source:  BioPlex,STRINGDB
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.823003786
p_ni:  0.176996214
Data Source:  BioPlex
Publication Statistics
PubMed Score  30.53

PubMed score by year
PubTator Score  14.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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