Tbio RHBDF2 Inactive rhomboid protein 2

Protein Summary

Description

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity).

Uniprot Accession IDs

• Q6PJF5
• A6NEM3
• A8K801
• Q5U607
• Q5YGQ8
• Q9H6E9
• iRhom2

Gene Name

• RHBDF2

Ensembl ID

• ENST00000313080
• ENSP00000322775
• ENSG00000129667
• ENST00000591885
• ENSP00000466867

Symbol

• IRHOM2
• RHBDL5
• RHBDL6
• TEC
• TOC
• TOCG
• RHBDL5
• RHBDL6
• iRhom2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.85
cell line	0.66
cellular component	0.66
tissue sample	0.66
transcription factor	0.66

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Inactive Rhomboid Protein 2

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Inactive Rhomboid Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.6   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 61   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.6   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0