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Tbio
TRIM65
Tripartite motif-containing protein 65

IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.28   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.28   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
95
white matter hyperintensity measurement
2
2
1
12.5
90.2
body mass index
1
1
1
24.8
reticulocyte count
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
95
white matter hyperintensity measurement
1
12.5
90.2
body mass index
1
24.8
reticulocyte count
1
13.2
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (28)
1 – 10 of 28
CRYL1
Tbio
Family: Enzyme
Novelty: 0.04513297
p_int: 0.996970524
p_ni: 0.003029435
p_wrong: 4.1e-8
Data Source: BioPlex
SHARPIN
Tbio
Novelty: 0.0197352
p_int: 0.996054798
p_ni: 0.003934586
p_wrong: 0.000010615
Score: 0.194
Data Source: BioPlex,STRINGDB
SNX21
Tdark
Novelty: 0.32916633
p_int: 0.995798984
p_ni: 0.004200798
p_wrong: 2.18e-7
Score: 0.159
Data Source: BioPlex,STRINGDB
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
p_int: 0.986417143
p_ni: 0.013545026
p_wrong: 0.000037832
Data Source: BioPlex
GATD1
Tdark
Family: Enzyme
Novelty: 0.40291197
p_int: 0.982394485
p_ni: 0.017575326
p_wrong: 0.000030189
Data Source: BioPlex
DOCK5
Tbio
Novelty: 0.03153692
p_int: 0.926977637
p_ni: 0.072985411
p_wrong: 0.000036952
Data Source: BioPlex
KDELC1
Tbio
Novelty: 0.10139587
p_int: 0.909876727
p_ni: 0.048571803
p_wrong: 0.041551471
Data Source: BioPlex
CCNJL
Tdark
Novelty: 2.86306774
p_int: 0.890127616
p_ni: 0.109849131
p_wrong: 0.000023253
Score: 0.198
Data Source: BioPlex,STRINGDB
HPS5
Tbio
Novelty: 0.05155851
p_int: 0.824449778
p_ni: 0.146515556
p_wrong: 0.029034666
Data Source: BioPlex
P4HA2
Tbio
Family: Enzyme
Novelty: 0.02097718
p_int: 0.772816495
p_ni: 0.008551743
p_wrong: 0.218631762
Data Source: BioPlex
Publication Statistics
PubMed Score  13.28

PubMed score by year
PubTator Score  6.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer