You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
SPSB3
SPRY domain-containing SOCS box protein 3

Protein Summary
Description
May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301717
  • ENSP00000301717
  • ENSG00000162032
  • ENST00000566339
  • ENSP00000457206

Symbol
  • C16orf31
  • SSB3
  • SSB3
  • C16orf31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
histone modification site profile
0.86
kinase perturbation
0.81
transcription factor
0.71
cell type or tissue
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.3   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.3   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (177)
1 – 10 of 177
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.999997548
p_ni:  0.000002452
Score:  0.955
Data Source:  BioPlex,STRINGDB
UXS1
Tbio
Family:  Enzyme
Novelty:  0.04671281
p_int:  0.999981755
p_ni:  0.000018245
Data Source:  BioPlex
SMYD1
Tbio
Family:  Epigenetic
Novelty:  0.03781475
p_int:  0.999973367
p_ni:  0.00002657
p_wrong:  6.3e-8
Score:  0.345
Data Source:  BioPlex,STRINGDB
KDELC1
Tbio
Novelty:  0.10139587
p_int:  0.999889508
p_ni:  0.000099974
p_wrong:  0.000010519
Data Source:  BioPlex
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.999827162
p_ni:  0.000145622
p_wrong:  0.000027217
Score:  0.917
Data Source:  BioPlex,STRINGDB
LYPD1
Tbio
Novelty:  0.10740408
p_int:  0.999784831
p_ni:  0.000215085
p_wrong:  8.3e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
CDK13
Tchem
Family:  Kinase
Novelty:  0.03084808
p_int:  0.999615966
p_ni:  0.000383856
p_wrong:  1.78e-7
Score:  0.163
Data Source:  BioPlex,STRINGDB
KLK11
Tbio
Family:  Enzyme
Novelty:  0.00267977
p_int:  0.999001572
p_ni:  0.000263259
p_wrong:  0.000735169
Score:  0.224
Data Source:  BioPlex,STRINGDB
RPGR
Tbio
Family:  Enzyme
Novelty:  0.002733
p_int:  0.998182666
p_ni:  0.001815977
p_wrong:  0.000001357
Score:  0.198
Data Source:  BioPlex,STRINGDB
GNA13
Tbio
Novelty:  0.04149138
p_int:  0.998051371
p_ni:  0.000950887
p_wrong:  0.000997742
Data Source:  BioPlex
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
7
7
98.8
appendicular lean mass
3
1
3
75.7
sex hormone-binding globulin measurement
2
1
2
56.4
blood metabolite measurement
1
1
1
49.5
platelet crit
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
7
98.8
appendicular lean mass
3
75.7
sex hormone-binding globulin measurement
2
56.4
blood metabolite measurement
1
49.5
platelet crit
1
33.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
splA/ryanodine receptor domain and SOCS box containing 3
VGNC:9109
453826
Macaque
splA/ryanodine receptor domain and SOCS box containing 3
722489
Mouse
MGI:1891471
79043
Rat
RGD:1310936
302981
Dog
splA/ryanodine receptor domain and SOCS box containing 3
VGNC:46771
490071
Species
Name
OMA
EggNOG
Inparanoid
Chimp
splA/ryanodine receptor domain and SOCS box containing 3
Macaque
splA/ryanodine receptor domain and SOCS box containing 3
Mouse
Rat
Dog
splA/ryanodine receptor domain and SOCS box containing 3
Publication Statistics
PubMed Score 13.30
PubMed score by year
PubTator Score 2.10
PubTator score by year