Tdark SPSB3 SPRY domain-containing SOCS box protein 3

Protein Summary

Description

May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Uniprot Accession IDs

• Q6PJ21
• D3DU78
• Q49A96
• Q86X18
• Q8WXK5
• Q96IE6
• Q96RY2
• SSB-3

Gene Name

• SPSB3

Ensembl ID

• ENST00000301717
• ENSP00000301717
• ENSG00000162032
• ENST00000566339
• ENSP00000457206

Symbol

• C16orf31
• SSB3
• SSB3
• C16orf31

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
histone modification site profile	0.86
kinase perturbation	0.81
transcription factor	0.71
cell type or tissue	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.07   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 33   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.07   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0