You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TRAT1
T-cell receptor-associated transmembrane adapter 1

Protein Summary
Description
Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295756
  • ENSP00000295756
  • ENSG00000163519

Symbol
  • TCRIM
  • TRIM
  • TCRIM
  • HSPC062
  • pp29/30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.95
gene perturbation
0.59
virus perturbation
0.55
biological process
0.54
cell type or tissue
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.28   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.28   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
1
1
0
1.1
35.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
0
1.1
35.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T cell receptor associated transmembrane adaptor 1
VGNC:7134
741922
Macaque
T-cell receptor-associated transmembrane adapter 1
705946
Mouse
MGI:1924897
77647
Rat
RGD:1563011
498075
Dog
T cell receptor associated transmembrane adaptor 1
VGNC:47789
478556
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T cell receptor associated transmembrane adaptor 1
Macaque
T-cell receptor-associated transmembrane adapter 1
Mouse
Rat
Dog
T cell receptor associated transmembrane adaptor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6PIZ9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream TCR signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Constitutive Signaling by Aberrant PI3K in Cancer
Disease
Diseases of signal transduction
Downstream TCR signaling
Protein-Protein Interactions (143)
1 – 10 of 143
DACT3
Tbio
Novelty: 0.04684884
p_int: 0.999994706
p_ni: 0.000003851
p_wrong: 0.000001443
Data Source: BioPlex
GOPC
Tbio
Novelty: 0.01110168
p_int: 0.991176139
p_ni: 0.00882386
Data Source: BioPlex
PLXDC2
Tbio
Novelty: 0.06496695
p_int: 0.967112782
p_ni: 0.032887218
Data Source: BioPlex
ACADVL
Tbio
Family: Enzyme
Novelty: 0.00383705
p_int: 0.872171225
p_ni: 0.127286292
p_wrong: 0.000542483
Data Source: BioPlex
FHL2
Tbio
Novelty: 0.00501273
p_int: 0.809319701
p_ni: 0.190680295
p_wrong: 5e-9
Data Source: BioPlex
GRN
Tbio
Novelty: 0.00096395
p_int: 0.791441168
p_ni: 0.208553141
p_wrong: 0.000005691
Data Source: BioPlex
CD247
Tbio
Novelty: 0.00217194
Score: 0.977
Data Source: STRINGDB
CD3E
Tclin
Novelty: 0.0053855
Score: 0.968
Data Source: STRINGDB
CD3D
Tclin
Novelty: 0.00510314
Score: 0.964
Data Source: STRINGDB
ZAP70
Tchem
Family: Kinase
Novelty: 0.0011564
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  551.28

PubMed score by year
PubTator Score  27.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: