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Tchem
NCEH1
Neutral cholesterol ester hydrolase 1

Protein Summary
Description
Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000543711
  • ENSP00000443227
  • ENSG00000144959

Symbol
  • AADACL1
  • KIAA1363
  • NCEH
  • AADACL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
transcription factor binding site profile
0.93
microRNA
0.77
kinase perturbation
0.66
transcription factor
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.46   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.46   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (14)
Protein-Protein Interactions (72)
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.999993796
p_ni:  0.000006204
p_wrong:  1e-9
Data Source:  BioPlex
UGT3A2
Tbio
Family:  Enzyme
Novelty:  0.35904542
p_int:  0.999920469
p_ni:  0.000071737
p_wrong:  0.000007794
Score:  0.15
Data Source:  BioPlex,STRINGDB
NRN1
Tbio
Novelty:  0.01198116
p_int:  0.999723887
p_ni:  0.00021586
p_wrong:  0.000060252
Data Source:  BioPlex
LRRC3
Tdark
Novelty:  0.13484671
p_int:  0.999110105
p_ni:  0.000863908
p_wrong:  0.000025987
Data Source:  BioPlex
TMEM231
Tbio
Novelty:  0.17100188
p_int:  0.998793031
p_ni:  0.001206951
p_wrong:  1.8e-8
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.998553369
p_ni:  0.001441681
p_wrong:  0.00000495
Data Source:  BioPlex
ST3GAL6
Tbio
Family:  Enzyme
Novelty:  0.05226811
p_int:  0.997515628
p_ni:  0.002347568
p_wrong:  0.000136804
Score:  0.181
Data Source:  BioPlex,STRINGDB
CANT1
Tbio
Family:  Enzyme
Novelty:  0.02640333
p_int:  0.995205084
p_ni:  0.004794292
p_wrong:  6.23e-7
Score:  0.16
Data Source:  BioPlex,STRINGDB
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.993534864
p_ni:  0.00638644
p_wrong:  0.000078696
Score:  0.17
Data Source:  BioPlex,STRINGDB
ALG9
Tbio
Family:  Enzyme
Novelty:  0.02975572
p_int:  0.98718881
p_ni:  0.012810669
p_wrong:  5.21e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
LDL clearance (R-HSA-8964038)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
LDL clearance
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein clearance
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
LDL clearance
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein clearance
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
4
11
96.5
serum gamma-glutamyl transferase measurement
2
2
2
92.2
TNF-related activation-induced cytokine measurement
1
1
1
86.1
monocyte percentage of leukocytes
1
2
2
77.9
platelet crit
2
1
2
72.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
11
96.5
serum gamma-glutamyl transferase measurement
2
92.2
TNF-related activation-induced cytokine measurement
1
86.1
monocyte percentage of leukocytes
2
77.9
platelet crit
2
72.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neutral cholesterol ester hydrolase 1
VGNC:11989
470998
Macaque
neutral cholesterol ester hydrolase 1
694200
Mouse
MGI:2443191
320024
Rat
RGD:1311104
294930
Dog
neutral cholesterol ester hydrolase 1
VGNC:43649
488171
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neutral cholesterol ester hydrolase 1
Macaque
neutral cholesterol ester hydrolase 1
Mouse
Rat
Dog
neutral cholesterol ester hydrolase 1
Publication Statistics
PubMed Score 69.46
PubMed score by year
PubTator Score 18.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title