Tbio KCNIP4 Kv channel-interacting protein 4

Protein Summary

Description

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents (PubMed:23576435). Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440). Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q6PIL6
• Q3YAB8
• Q3YAB9
• Q3YAC0
• Q3YAC1
• Q3YAC2
• Q4W5G8
• Q8NEU0
• Q9BWT2
• Q9H294
• Q9H2A4
• KChIP4

Gene Name

• KCNIP4

Ensembl ID

• ENST00000359001
• ENSP00000351892
• ENSG00000185774
• ENST00000382148
• ENSP00000371583
• ENST00000382150
• ENSP00000371585
• ENST00000382152
• ENSP00000371587
• ENST00000447367
• ENSP00000399080
• ENST00000509207
• ENSP00000423257

Symbol

• CALP
• KCHIP4
• CALP
• KCHIP4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
molecular function	0.9
disease	0.69
microRNA	0.68
cellular component	0.66

Protein Classes

DTO Classes

Protein / Ion Channel / The Phagocyte (Gp91(phox)) Nadph Oxidase Family / Kv Channel-interacting Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.76   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.76   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0