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Tdark
HAGHL
Hydroxyacylglutathione hydrolase-like protein

Protein Summary
Description
Hydrolase acting on ester bonds.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341413
  • ENSP00000341952
  • ENSG00000103253
  • ENST00000389703
  • ENSP00000374353
  • ENST00000549114
  • ENSP00000447170
  • ENST00000564537
  • ENSP00000457219
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.68
cellular component
0.64
histone modification site profile
0.57
transcription factor
0.5
tissue sample
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.2   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.2   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (21)
1 – 10 of 21
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.999977008
p_ni:  1e-9
p_wrong:  0.000022991
Score:  0.214
Data Source:  BioPlex,STRINGDB
PRR29
Tdark
Novelty:  48
Score:  0.671
Data Source:  STRINGDB
MBLAC1
Tdark
Family:  Enzyme
Novelty:  0.48250122
Score:  0.653
Data Source:  STRINGDB
MBLAC2
Tdark
Family:  Enzyme
Novelty:  0.47407992
Score:  0.65
Data Source:  STRINGDB
CSRNP2
Tdark
Novelty:  0.95252026
Score:  0.596
Data Source:  STRINGDB
C1orf174
Tdark
Novelty:  4.20172485
Score:  0.587
Data Source:  STRINGDB
NMRAL1
Tbio
Novelty:  0.06152541
Score:  0.572
Data Source:  STRINGDB
DHX32
Tbio
Family:  Enzyme
Novelty:  0.09993874
Score:  0.556
Data Source:  STRINGDB
KIAA2026
Tdark
Family:  Epigenetic
Novelty:  0.92750263
Score:  0.526
Data Source:  STRINGDB
EPN3
Tbio
Novelty:  0.12685855
Score:  0.511
Data Source:  STRINGDB
Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
9
10
91.7
BMI-adjusted waist circumference
1
7
7
82.8
cancer antigen 125 measurement
1
3
3
77.9
mean corpuscular volume
1
1
1
74.6
mean reticulocyte volume
1
1
1
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
10
91.7
BMI-adjusted waist circumference
7
82.8
cancer antigen 125 measurement
3
77.9
mean corpuscular volume
1
74.6
mean reticulocyte volume
1
72.3
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
hydroxyacylglutathione hydrolase like
697846
Mouse
MGI:1919877
68977
Dog
hydroxyacylglutathione hydrolase like
VGNC:41586
490087
Horse
hydroxyacylglutathione hydrolase like
VGNC:18685
100067135
Cow
hydroxyacylglutathione hydrolase like
VGNC:29743
511836
Species
Name
OMA
EggNOG
Inparanoid
Macaque
hydroxyacylglutathione hydrolase like
Mouse
Dog
hydroxyacylglutathione hydrolase like
Horse
hydroxyacylglutathione hydrolase like
Cow
hydroxyacylglutathione hydrolase like
Publication Statistics
PubMed Score 2.20
PubMed score by year
PubTator Score 0.50
PubTator score by year