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Tbio
SYCE2
Synaptonemal complex central element protein 2

Protein Summary
Description
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity). The protein encoded by this gene is part of the synaptonemal complex formed between homologous chromosomes during meiotic prophase. The encoded protein associates with SYCP1 and SYCE1 and is found only where chromosome cores are synapsed. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293695
  • ENSP00000293695
  • ENSG00000161860

Symbol
  • CESC1
  • CESC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
histone modification site profile
0.69
tissue sample
0.59
gene perturbation
0.55
tissue
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.05   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.05   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
TEX12
Tbio
Novelty:  0.11828137
Score:  0.994
Data Source:  Reactome,STRINGDB
SYCP1
Tbio
Novelty:  0.01493554
Score:  0.993
Data Source:  STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
Score:  0.993
Data Source:  Reactome,STRINGDB
SYCE3
Tdark
Novelty:  0.22361224
Score:  0.992
Data Source:  Reactome,STRINGDB
SYCP2
Tbio
Novelty:  0.05040533
Score:  0.98
Data Source:  STRINGDB
SYCP3
Tbio
Novelty:  0.00443901
Score:  0.972
Data Source:  STRINGDB
REC8
Tbio
Novelty:  0.00732742
Score:  0.966
Data Source:  STRINGDB
STAG3
Tbio
Novelty:  0.03329703
Score:  0.965
Data Source:  STRINGDB
SMC1B
Tbio
Novelty:  0.0369537
Score:  0.957
Data Source:  STRINGDB
RAD21
Tbio
Novelty:  0.00270936
Score:  0.937
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic synapsis
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic synapsis
Reproduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Sequence or structural Similarity (ISS)
HGNC
Disease Associations (null)
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
7
7
98.4
reticulocyte measurement
3
5
6
97.9
mean corpuscular hemoglobin concentration
3
3
3
97
erythrocyte count
3
5
5
96.7
reticulocyte count
7
4
8
96.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
7
98.4
reticulocyte measurement
6
97.9
mean corpuscular hemoglobin concentration
3
97
erythrocyte count
5
96.7
reticulocyte count
8
96.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptonemal complex central element protein 2
VGNC:2236
747076
Macaque
synaptonemal complex central element protein 2
100431090
Mouse
MGI:1919096
71846
Rat
RGD:1311867
364976
Dog
synaptonemal complex central element protein 2
VGNC:47015
484923
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptonemal complex central element protein 2
Macaque
synaptonemal complex central element protein 2
Mouse
Rat
Dog
synaptonemal complex central element protein 2
Publication Statistics
PubMed Score 6.05
PubMed score by year
PubTator Score 2.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title