You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
KLHDC10
Kelch domain-containing protein 10

Protein Summary
Description
Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335420
  • ENSP00000334140
  • ENSG00000128607

Symbol
  • KIAA0265
  • slim
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
transcription factor perturbation
0.88
transcription factor binding site profile
0.86
kinase perturbation
0.76
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (41)
1 – 10 of 41
IKZF1
Tbio
Family: TF
Novelty: 0.00201134
p_int: 0.999993026
p_ni: 0.000006973
p_wrong: 1e-9
Score: 0.207
Data Source: BioPlex,STRINGDB
PYCR1
Tbio
Family: Enzyme
Novelty: 0.00252839
p_int: 0.999990057
p_ni: 0.000009788
p_wrong: 1.55e-7
Score: 0.532
Data Source: BioPlex,STRINGDB
CUL2
Tbio
Novelty: 0.00892549
p_int: 0.999985242
p_ni: 0.000002824
p_wrong: 0.000011934
Score: 0.59
Data Source: BioPlex,STRINGDB
KITLG
Tbio
Novelty: 0.00051952
p_int: 0.999962722
p_ni: 0.00003727
p_wrong: 8e-9
Score: 0.455
Data Source: BioPlex,STRINGDB
GLMN
Tbio
Novelty: 0.01373749
p_int: 0.999622342
p_ni: 0.000028997
p_wrong: 0.000348661
Data Source: BioPlex
DEFA5
Tbio
Novelty: 0.01045537
p_int: 0.999218853
p_ni: 0.000626229
p_wrong: 0.000154918
Data Source: BioPlex
MKLN1
Tbio
Novelty: 0.07307009
Score: 0.722
Data Source: STRINGDB
KLHDC7A
Tdark
Novelty: 3.33333333
Score: 0.636
Data Source: STRINGDB
BSDC1
Tdark
Novelty: 5
Score: 0.591
Data Source: STRINGDB
ZC3HC1
Tbio
Novelty: 0.00685121
Score: 0.578
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.00

PubMed score by year
PubTator Score  9.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: