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Tdark
TTC33
Tetratricopeptide repeat protein 33

Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.66   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.66   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum urea measurement
2
3
3
97.8
blood urea nitrogen measurement
2
2
2
94.7
6
3
0
1.3
92.2
hemoglobin measurement
3
2
3
73.4
5
4
2
1.4
71.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum urea measurement
3
97.8
blood urea nitrogen measurement
2
94.7
0
1.3
92.2
hemoglobin measurement
3
73.4
2
1.4
71.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 33
VGNC:4214
461904
Mouse
MGI:1914765
67515
Rat
RGD:1564042
294774
Dog
tetratricopeptide repeat domain 33
VGNC:47953
479352
Horse
tetratricopeptide repeat domain 33
VGNC:24626
100053158
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 33
Mouse
Rat
Dog
tetratricopeptide repeat domain 33
Horse
tetratricopeptide repeat domain 33
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6PID6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (43)
1 – 10 of 43
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.999999853
p_ni:  1.26e-7
p_wrong:  2.1e-8
Data Source:  BioPlex
CCDC97
Tdark
Novelty:  2.36351796
p_int:  0.999998824
p_ni:  0.000001176
Score:  0.663
Data Source:  BioPlex,STRINGDB
ZRSR2
Tbio
Novelty:  0.03449891
p_int:  0.991624038
p_ni:  0.008375605
p_wrong:  3.58e-7
Score:  0.202
Data Source:  BioPlex,STRINGDB
ANKRD18A
Tdark
Novelty:  0.52739857
p_int:  0.877813482
p_ni:  0.1188841
p_wrong:  0.003302418
Score:  0.288
Data Source:  BioPlex,STRINGDB
E2F8
Tbio
Family:  TF
Novelty:  0.0095081
p_int:  0.873809531
p_ni:  0.123440559
p_wrong:  0.00274991
Score:  0.54
Data Source:  BioPlex,STRINGDB
LITAF
Tbio
Family:  TF
Novelty:  0.0097203
p_int:  0.849450805
p_ni:  0.145828264
p_wrong:  0.004720931
Data Source:  BioPlex
ORMDL1
Tbio
Novelty:  0.1323746
p_int:  0.842203136
p_ni:  0.157790973
p_wrong:  0.00000589
Score:  0.207
Data Source:  BioPlex,STRINGDB
CCDC83
Tdark
Novelty:  0.2258549
p_int:  0.830684576
p_ni:  0.164155758
p_wrong:  0.005159666
Score:  0.243
Data Source:  BioPlex,STRINGDB
C16orf45
Tbio
Novelty:  0.00913059
p_int:  0.813030692
p_ni:  0.186964198
p_wrong:  0.00000511
Score:  0.198
Data Source:  BioPlex,STRINGDB
NUDT4
Tbio
Family:  Enzyme
Novelty:  0.05544881
Score:  0.583
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.66

PubMed score by year
PubTator Score  1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer