Tbio SHQ1 Protein SHQ1 homolog

Protein Summary

Description

Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs, modification of spliceosomal small nuclear RNAs, and stabilization of telomerase (see MIM 602322) (Grozdanov et al., 2009 [PubMed 19383767]).[supplied by OMIM, Dec 2010]

Uniprot Accession IDs

• Q6PI26
• B4DL05
• Q6MZJ4
• Q7Z748
• Q9H7E5
• Q9NVS8

Gene Name

• SHQ1

Ensembl ID

• ENST00000325599
• ENSP00000315182
• ENSG00000144736
• ENST00000463369
• ENSP00000417452

Symbol

• Shq1p
• GRIM-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
transcription factor binding site profile	0.78
kinase perturbation	0.76
tissue sample	0.56
cellular component	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.13   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.13   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0