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Tchem
ULK3
Serine/threonine-protein kinase ULK3

Protein Summary
Description
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000440863
  • ENSP00000400312
  • ENSG00000140474
  • ENST00000568667
  • ENSP00000457853
  • ENST00000569437
  • ENSP00000456051
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
molecular function
0.91
drug perturbation
0.87
protein domain
0.85
small molecule
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.37   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 347   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.37   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 347   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Hedgehog 'on' state (R-HSA-5632684)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hedgehog 'on' state
Reactome
Signal Transduction
Reactome
Signaling by Hedgehog
Name
Explore in Pharos
Explore in Source
Hedgehog 'on' state
Signal Transduction
Signaling by Hedgehog
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (71)
1 – 10 of 71
BCAN
Tbio
Novelty: 0.00960788
p_int: 0.99997977
p_ni: 3.5e-8
p_wrong: 0.000020195
Score: 0.622
Data Source: BioPlex,STRINGDB
FKBP5
Tchem
Family: Enzyme
Novelty: 0.00252437
p_int: 0.988143104
p_ni: 0.011856896
Score: 0.189
Data Source: BioPlex,STRINGDB
AIP
Tbio
Novelty: 0.00986784
p_int: 0.750682944
p_ni: 0.249317056
Score: 0.534
Data Source: BioPlex,STRINGDB
GLI1
Tchem
Family: TF
Novelty: 0.00090982
Score: 0.989
Data Source: Reactome,STRINGDB
GLI2
Tchem
Family: TF
Novelty: 0.00238748
Score: 0.972
Data Source: Reactome,STRINGDB
IST1
Tbio
Novelty: 0.02520613
Score: 0.971
Data Source: STRINGDB
GLI3
Tbio
Family: TF
Novelty: 0.00059889
Score: 0.951
Data Source: Reactome,STRINGDB
SUFU
Tbio
Novelty: 0.00485324
Score: 0.928
Data Source: Reactome,STRINGDB
ATG101
Tbio
Novelty: 0.07411874
Score: 0.815
Data Source: STRINGDB
MTOR
Tclin
Family: Kinase
Novelty: 0.00014431
Score: 0.809
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.37

PubMed score by year
PubTator Score  8.48

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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