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Tdark
DCUN1D2
DCN1-like protein 2

Protein Summary
Description
Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375403
  • ENSP00000364552
  • ENSG00000150401
  • ENST00000478244
  • ENSP00000417706

Symbol
  • C13orf17
  • DCUN1L2
  • C13orf17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
transcription factor binding site profile
0.73
cell type or tissue
0.62
microRNA
0.6
transcription factor
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.08   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.08   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
45.8
monocyte percentage of leukocytes
1
1
1
20.5
birth weight
1
1
1
19.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
45.8
monocyte percentage of leukocytes
1
20.5
birth weight
1
19.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defective in cullin neddylation 1 domain containing 2
VGNC:13077
452680
Macaque
defective in cullin neddylation 1 domain containing 2
715099
Mouse
MGI:2142792
102323
Rat
RGD:9432541
103694000
Horse
defective in cullin neddylation 1 domain containing 2
VGNC:17063
100067313
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defective in cullin neddylation 1 domain containing 2
Macaque
defective in cullin neddylation 1 domain containing 2
Mouse
Rat
Horse
defective in cullin neddylation 1 domain containing 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6PH85-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Protein-Protein Interactions (211)
1 – 10 of 211
USP25
Tbio
Family: Enzyme
Novelty: 0.03671706
p_int: 0.999927703
p_ni: 0.000072297
p_wrong: 1e-9
Score: 0.289
Data Source: BioPlex,STRINGDB
ZC3HC1
Tbio
Novelty: 0.089692
p_int: 0.999492546
p_ni: 0.000507394
p_wrong: 6e-8
Data Source: BioPlex
KLHL42
Tdark
Novelty: 0.25822395
p_int: 0.998384316
p_ni: 0.001615433
p_wrong: 2.51e-7
Score: 0.9
Data Source: BioPlex,STRINGDB
INPPL1
Tchem
Family: Enzyme
Novelty: 0.00634126
p_int: 0.992760937
p_ni: 0.007239063
Data Source: BioPlex
KLHL18
Tdark
Novelty: 0.52915213
p_int: 0.99168441
p_ni: 0.008007688
p_wrong: 0.000307903
Data Source: BioPlex
SCRIB
Tbio
Novelty: 0.01099525
p_int: 0.982377621
p_ni: 0.017622379
Data Source: BioPlex
FEM1B
Tbio
Novelty: 0.06746412
p_int: 0.981986204
p_ni: 0.018013796
Score: 0.905
Data Source: BioPlex,STRINGDB
GAP43
Tbio
Novelty: 0.00091023
p_int: 0.969928449
p_ni: 0.020405854
p_wrong: 0.009665697
Data Source: BioPlex
CUL4B
Tbio
Novelty: 0.0133075
p_int: 0.906105121
p_ni: 0.093894879
Score: 0.964
Data Source: BioPlex,STRINGDB
KLHL24
Tbio
Novelty: 0.04032749
p_int: 0.896929377
p_ni: 0.103070622
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  1.08

PubMed score by year
PubTator Score  0.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer