Tchem DCUN1D2 DCN1-like protein 2

Protein Summary

Description

Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

Uniprot Accession IDs

• Q6PH85
• Q5JSA5
• Q5JSA6
• Q5JSA7
• Q9NVJ1
• Q9NXR6

Gene Name

• DCUN1D2

Ensembl ID

• ENST00000375403
• ENSP00000364552
• ENSG00000150401
• ENST00000478244
• ENSP00000417706

Symbol

• C13orf17
• DCUN1L2
• C13orf17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
transcription factor binding site profile	0.73
cell type or tissue	0.62
microRNA	0.6
transcription factor	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.18   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 86   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.18   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0