Protein Summary
Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
- ENST00000375403
- ENSP00000364552
- ENSG00000150401
- ENST00000478244
- ENSP00000417706
- C13orf17
- DCUN1L2
- C13orf17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.83 | ||
transcription factor binding site profile | 0.73 | ||
cell type or tissue | 0.62 | ||
microRNA | 0.6 | ||
transcription factor | 0.59 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.08 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 86 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.08 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 86 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (3)
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1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 1 | 1 | 1 | 45.8 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 20.5 | |||||
birth weight | 1 | 1 | 1 | 19.8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 1 | 45.8 | |||||
monocyte percentage of leukocytes | 1 | 20.5 | |||||
birth weight | 1 | 19.8 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | defective in cullin neddylation 1 domain containing 2 | VGNC:13077 | 452680 | |||||
Macaque | defective in cullin neddylation 1 domain containing 2 | 715099 | ||||||
Mouse | MGI:2142792 | 102323 | ||||||
Rat | RGD:9432541 | 103694000 | ||||||
Horse | defective in cullin neddylation 1 domain containing 2 | VGNC:17063 | 100067313 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | defective in cullin neddylation 1 domain containing 2 | |||||
Macaque | defective in cullin neddylation 1 domain containing 2 | |||||
Mouse | ||||||
Rat | ||||||
Horse | defective in cullin neddylation 1 domain containing 2 | |||||
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Neddylation | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Neddylation | ||||
Post-translational protein modification | ||||
Gene Ontology Terms (6)
Functions (3)
Components (1)
Processes (2)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (211)
1 – 10 of 211
USP25
Family: Enzyme
Novelty: 0.03671706
p_int: 0.999927703
p_ni: 0.000072297
p_wrong: 1e-9
Score: 0.289
Data Source: BioPlex,STRINGDB
ZC3HC1
Novelty: 0.089692
p_int: 0.999492546
p_ni: 0.000507394
p_wrong: 6e-8
Data Source: BioPlex
KLHL42
Novelty: 0.25822395
p_int: 0.998384316
p_ni: 0.001615433
p_wrong: 2.51e-7
Score: 0.9
Data Source: BioPlex,STRINGDB
INPPL1
Family: Enzyme
Novelty: 0.00634126
p_int: 0.992760937
p_ni: 0.007239063
Data Source: BioPlex
KLHL18
Novelty: 0.52915213
p_int: 0.99168441
p_ni: 0.008007688
p_wrong: 0.000307903
Data Source: BioPlex
SCRIB
Novelty: 0.01099525
p_int: 0.982377621
p_ni: 0.017622379
Data Source: BioPlex
FEM1B
Novelty: 0.06746412
p_int: 0.981986204
p_ni: 0.018013796
Score: 0.905
Data Source: BioPlex,STRINGDB
GAP43
Novelty: 0.00091023
p_int: 0.969928449
p_ni: 0.020405854
p_wrong: 0.009665697
Data Source: BioPlex
CUL4B
Novelty: 0.0133075
p_int: 0.906105121
p_ni: 0.093894879
Score: 0.964
Data Source: BioPlex,STRINGDB
KLHL24
Novelty: 0.04032749
p_int: 0.896929377
p_ni: 0.103070622
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score 1.08
PubMed score by year
PubTator Score 0.11
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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