Tchem DCUN1D2 DCN1-like protein 2

Protein Summary

Description

Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

Uniprot Accession IDs

• Q6PH85
• Q5JSA5
• Q5JSA6
• Q5JSA7
• Q9NVJ1
• Q9NXR6

Gene Name

• DCUN1D2

Ensembl ID

• ENST00000375403
• ENSP00000364552
• ENSG00000150401
• ENST00000478244
• ENSP00000417706

Symbol

• C13orf17
• DCUN1L2
• C13orf17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
transcription factor binding site profile	0.73
cell type or tissue	0.62
microRNA	0.6
transcription factor	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.08   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 86   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.08   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

CHEMBL4592844

DCUN1D2Tchem

pKi : 8.67

Protein-Protein Interactions (211)

Explore Interacting Targets

1 – 10 of 211

• See Interactions on String-DB

USP25

Tchem

Family:  Enzyme

Novelty:  0.03671706

p_int:  0.999927703

p_ni:  0.000072297

p_wrong:  1e-9

Score:  0.289

Data Source:  BioPlex,STRINGDB

ZC3HC1

Tbio

Novelty:  0.089692

p_int:  0.999492546

p_ni:  0.000507394

p_wrong:  6e-8

Data Source:  BioPlex

KLHL42

Tdark

Novelty:  0.25822395

p_int:  0.998384316

p_ni:  0.001615433

p_wrong:  2.51e-7

Score:  0.9

Data Source:  BioPlex,STRINGDB

INPPL1

Tchem

Family:  Enzyme

Novelty:  0.00634126

p_int:  0.992760937

p_ni:  0.007239063

Data Source:  BioPlex

KLHL18

Tdark

Novelty:  0.52915213

p_int:  0.99168441

p_ni:  0.008007688

p_wrong:  0.000307903

Data Source:  BioPlex

SCRIB

Tbio

Novelty:  0.01099525

p_int:  0.982377621

p_ni:  0.017622379

Data Source:  BioPlex

FEM1B

Tbio

Novelty:  0.06746412

p_int:  0.981986204

p_ni:  0.018013796

Score:  0.905

Data Source:  BioPlex,STRINGDB

GAP43

Tbio

Novelty:  0.00091023

p_int:  0.969928449

p_ni:  0.020405854

p_wrong:  0.009665697

Data Source:  BioPlex

CUL4B

Tbio

Novelty:  0.0133075

p_int:  0.906105121

p_ni:  0.093894879

Score:  0.964

Data Source:  BioPlex,STRINGDB

KLHL24

Tbio

Novelty:  0.04032749

p_int:  0.896929377

p_ni:  0.103070622

p_wrong:  1e-9

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Neddylation	234 targets	R-HSA-8951664
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Neddylation	234 targets	R-HSA-8951664
Post-translational protein modification	1450 targets	R-HSA-597592

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (3)

Components (1)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
cullin family protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ubiquitin conjugating enzyme binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ubiquitin-like protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	4	5	6		98.6
platelet count	EFO_0004309	2	2	2		92.9
neutrophil count	EFO_0004833	2	2	2		89.5
myeloid white cell count	EFO_0007988	1	1	1		79.5
leukocyte count	EFO_0004308	1	1	1		73.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	6		98.6
platelet count	EFO_0004309	2		92.9
neutrophil count	EFO_0004833	2		89.5
myeloid white cell count	EFO_0007988	1		79.5
leukocyte count	EFO_0004308	1		73.7

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Phosphoprotein
Reference proteome
Ubl conjugation pathway

GWAS Trait Find Similar Targets

No Header	No Header
birth weight
electrocardiography
intraocular pressure measurement
leukocyte count
mean platelet volume
mean reticulocyte volume
monocyte percentage of leukocytes
myeloid white cell count
neutrophil count
neutrophil percentage of leukocytes

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	defective in cullin neddylation 1 domain containing 2	VGNC:13077	452680
Macaque	defective in cullin neddylation 1 domain containing 2		715099
Mouse	DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)	MGI:2142792	102323
Rat	DCN1, defective in cullin neddylation 1, domain containing 2	RGD:9432541	103694000
Horse	defective in cullin neddylation 1 domain containing 2	VGNC:17063	100067313

Species	Name	OMA	EggNOG	Inparanoid
Chimp	defective in cullin neddylation 1 domain containing 2
Macaque	defective in cullin neddylation 1 domain containing 2
Mouse	DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)
Rat	DCN1, defective in cullin neddylation 1, domain containing 2
Horse	defective in cullin neddylation 1 domain containing 2

Publication Statistics

PubMed Score 1.08

PubMed score by year

Reset Zoom

PubTator Score 0.11

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (8)

Items per page:

10

0 of 0

PMID	Year	Title