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Tdark
KLHL35
Kelch-like protein 35

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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.7   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.7   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 35
VGNC:11884
451425
Mouse
MGI:1919434
72184
Rat
RGD:1565895
308850
Dog
kelch like family member 35
VGNC:42468
609209
Cow
kelch like family member 35
VGNC:30661
539879
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 35
Mouse
Rat
Dog
kelch like family member 35
Cow
kelch like family member 35
Protein-Protein Interactions (26)
1 – 10 of 26
GPR146
Tbio
Family: GPCR
Novelty: 0.10269429
Score: 0.722
Data Source: STRINGDB
ADAM30
Tdark
Family: Enzyme
Novelty: 0.25395428
Score: 0.716
Data Source: STRINGDB
DLEU7
Tdark
Novelty: 0.08581635
Score: 0.716
Data Source: STRINGDB
CDH22
Tbio
Novelty: 0.0954279
Score: 0.7
Data Source: STRINGDB
CYP2W1
Tbio
Novelty: 0.03285348
Score: 0.676
Data Source: STRINGDB
CEND1
Tbio
Novelty: 0.04549072
Score: 0.673
Data Source: STRINGDB
DEGS2
Tbio
Family: Enzyme
Novelty: 0.02360852
Score: 0.656
Data Source: STRINGDB
TOP1MT
Tclin
Family: Enzyme
Novelty: 0.07525806
Score: 0.594
Data Source: STRINGDB
ZSCAN18
Tdark
Family: TF
Novelty: 0.38794947
Score: 0.593
Data Source: STRINGDB
CCDC8
Tbio
Novelty: 0.07526278
Score: 0.587
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.70

PubMed score by year
PubTator Score  2.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer