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Tchem
TUBA3E
Tubulin alpha-3E chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. This gene encodes an alpha tubulin that highly conserved among species. A missense mutation in this gene has been potentially linked to microlissencephaly and global developmental delay. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312988
  • ENSP00000318197
  • ENSG00000152086
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
molecular function
0.94
protein domain
0.92
interacting protein
0.77
virus perturbation
0.55


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.5   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.5   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Pathways (15)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Formation of tubulin folding intermediates by CCT/TriC
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Formation of tubulin folding intermediates by CCT/TriC
Metabolism of proteins
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (100)
1 – 10 of 100
TCP11L2
Tdark
Novelty: 1.78903335
p_int: 0.999782497
p_ni: 0.000189347
p_wrong: 0.000028157
Score: 0.625
Data Source: BioPlex,STRINGDB
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.876215509
p_ni: 0.123784491
Score: 0.921
Data Source: BioPlex,STRINGDB
TUBB2B
Tclin
Novelty: 0.02905844
Score: 0.983
Data Source: STRINGDB
TUBB2A
Tclin
Novelty: 0.00902924
Score: 0.975
Data Source: STRINGDB
TUBB4A
Tclin
Novelty: 0.00045092
Score: 0.966
Data Source: STRINGDB
TUBB
Tclin
Novelty: 0.0038007
Score: 0.953
Data Source: STRINGDB
TBCE
Tbio
Novelty: 0.01058281
Score: 0.952
Data Source: STRINGDB
TUBB8
Tclin
Novelty: 0.06403117
Score: 0.95
Data Source: STRINGDB
TUBB3
Tclin
Novelty: 0.00195963
Score: 0.95
Data Source: STRINGDB
TUBB4B
Tclin
Novelty: 0.04120134
Score: 0.949
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.50

PubMed score by year
PubTator Score  0.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer