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Tbio
ZCCHC12
Zinc finger CCHC domain-containing protein 12

Protein Summary
Description
Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity). This gene encodes a downstream effector of bone morphogenetic protein (BMP) signalling. This protein contains a zinc finger domain and functions as a transcriptional coactivator. Variation in this gene may be associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310164
  • ENSP00000308921
  • ENSG00000174460

Symbol
  • SIZN1
  • SIZN
  • SIZN1
  • PNMA7A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.62
molecular function
0.56
tissue sample
0.54
biological process
0.44
histone modification site profile
0.44


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.45   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.45   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger CCHC-type containing 12
VGNC:7622
473755
Macaque
zinc finger CCHC-type containing 12
711072
Mouse
MGI:1919943
72693
Rat
RGD:1359439
313436
Dog
zinc finger CCHC-type containing 12
492090
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger CCHC-type containing 12
Macaque
zinc finger CCHC-type containing 12
Mouse
Rat
Dog
zinc finger CCHC-type containing 12
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Regulation of nuclear beta catenin signaling and target gene transcription
Name
Explore in Pharos
Explore in Source
Regulation of nuclear beta catenin signaling and target gene transcription
Protein-Protein Interactions (30)
1 – 10 of 30
PIAS4
Tbio
Family: TF
Novelty: 0.01388547
p_int: 0.999972746
p_ni: 1.24e-7
p_wrong: 0.00002713
Data Source: BioPlex
PNMA1
Tbio
Novelty: 0.06899807
p_int: 0.999458421
p_ni: 8.5e-8
p_wrong: 0.000541494
Score: 0.533
Data Source: BioPlex,STRINGDB
PGK2
Tbio
Family: Kinase
Novelty: 0.00832045
p_int: 0.920294505
p_ni: 0.079704499
p_wrong: 9.96e-7
Score: 0.209
Data Source: BioPlex,STRINGDB
CDR2L
Tbio
Novelty: 0.09295886
Score: 0.932
Data Source: STRINGDB
PNMA8A
Tdark
Novelty: 0.95674878
Score: 0.687
Data Source: STRINGDB
RTL9
Tbio
Novelty: 0.15059774
Score: 0.617
Data Source: STRINGDB
RTL5
Tdark
Novelty: 0.07868053
Score: 0.594
Data Source: STRINGDB
SMAD1
Tbio
Family: TF
Novelty: 0.02348173
Score: 0.583
Data Source: STRINGDB
RTL3
Tdark
Novelty: 0.27058386
Score: 0.561
Data Source: STRINGDB
LAMA3
Tbio
Novelty: 0.00733792
Score: 0.559
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.45

PubMed score by year
PubTator Score  5.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer