Tbio EMB Embigin

Protein Summary

Description

Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity). This gene encodes a transmembrane glycoprotein that is a member of the immunoglobulin superfamily. The encoded protein may be involved in cell growth and development by mediating interactions between the cell and extracellular matrix. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• Q6PCB8
• B7Z6S3
• B7Z902

Gene Name

• EMB

Ensembl ID

• ENST00000303221
• ENSP00000302289
• ENSG00000170571
• ENST00000514111
• ENSP00000426404

Symbol

• GP70

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
virus perturbation	0.94
kinase	0.85
PubMedID	0.82
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Embigin

DTO Classes

Protein / Receptor / Embigin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 773.25   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 184   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 773.25   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (42)

Explore Interacting Targets

1 – 10 of 42

• See Interactions on String-DB

SLC16A11

Tbio

Family:  Transporter

Novelty:  0.07860306

p_int:  0.999994912

p_ni:  0.000005087

p_wrong:  1e-9

Score:  0.398

Data Source:  BioPlex,STRINGDB

IL20

Tbio

Novelty:  0.78184288

p_int:  0.999459694

p_ni:  0.000536659

p_wrong:  0.000003646

Data Source:  BioPlex

LGALS3

Tchem

Novelty:  0.00032754

p_int:  0.99795564

p_ni:  0.002041252

p_wrong:  0.000003107

Score:  0.171

Data Source:  BioPlex,STRINGDB

FNDC11

Tdark

Novelty:  20.00979352

p_int:  0.997547356

p_ni:  0.002450325

p_wrong:  0.000002319

Score:  0.228

Data Source:  BioPlex,STRINGDB

LPCAT2

Tbio

Family:  Enzyme

Novelty:  0.02794035

p_int:  0.997380445

p_ni:  0.002512242

p_wrong:  0.000107313

Data Source:  BioPlex

HSD17B1

Tchem

Family:  Enzyme

Novelty:  0.00313425

p_int:  0.997334253

p_ni:  0.002489045

p_wrong:  0.000176702

Data Source:  BioPlex

DHRS9

Tbio

Family:  Enzyme

Novelty:  0.00256743

p_int:  0.997145736

p_ni:  0.002849958

p_wrong:  0.000004306

Score:  0.163

Data Source:  BioPlex,STRINGDB

OS9

Tbio

Novelty:  0.01490339

p_int:  0.996756746

p_ni:  0.003142908

p_wrong:  0.000100347

Score:  0.152

Data Source:  BioPlex,STRINGDB

RCL1

Tbio

Family:  Enzyme

Novelty:  0.02116964

p_int:  0.996172835

p_ni:  0.000876021

p_wrong:  0.002951144

Data Source:  BioPlex

LGALS8

Tchem

Novelty:  0.00623836

p_int:  0.995872191

p_ni:  0.004110958

p_wrong:  0.000016851

Data Source:  BioPlex

Pathways (4)

Reactome (4)

Proton-coupled monocarboxylate transport (R-HSA-433692)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Proton-coupled monocarboxylate transport	6 targets	R-HSA-433692
Reactome	SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Reactome	Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Proton-coupled monocarboxylate transport	6 targets	R-HSA-433692
SLC-mediated transmembrane transport	250 targets	R-HSA-425407
Transport of bile salts and organic acids, metal ions and amine compounds	86 targets	R-HSA-425366
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (11)

Functions (2)

Components (5)

Processes (4)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
cell-cell adhesion mediator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
monocarboxylic acid transmembrane transporter activity	Traceable Author Statement (TAS)	Reactome

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
schizophrenia	EFO_0000692	1	1	0	1.1	1.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
schizophrenia	EFO_0000692	0	1.1	1.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
schizophrenia

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
endocrine/exocrine gland phenotype
liver/biliary system phenotype
mortality/aging
reproductive system phenotype

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	embigin	VGNC:3977	461886
Macaque	embigin		702068
Mouse	embigin	MGI:95321	13723
Rat	embigin	RGD:621067	114511
Dog	embigin	VGNC:50876	479340

Species	Name	OMA	EggNOG	Inparanoid
Chimp	embigin
Macaque	embigin
Mouse	embigin
Rat	embigin
Dog	embigin

Publication Statistics

PubMed Score 773.25

PubMed score by year

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PubTator Score 299.07

PubTator score by year

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