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Tchem
SLC27A1
Long-chain fatty acid transport protein 1

Protein Summary
Description
Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane (PubMed:28178239). Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252595
  • ENSP00000252595
  • ENSG00000130304
  • ENST00000598424
  • ENSP00000472313

Symbol
  • ACSVL5
  • FATP1
  • FATP
  • FATP1
  • ACSVL5
  • FATP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
biological process
0.94
histone modification site profile
0.83
molecular function
0.73
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.31   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.31   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 34
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (34)
CHEMBL2377621
Rendered image for CHEMBL2377621
CHEMBL2377769
Rendered image for CHEMBL2377769
CHEMBL2377620
Rendered image for CHEMBL2377620
CHEMBL2377766
Rendered image for CHEMBL2377766
CHEMBL2058359
Rendered image for CHEMBL2058359
CHEMBL2377611
Rendered image for CHEMBL2377611
CHEMBL2377622
Rendered image for CHEMBL2377622
CHEMBL2377763
Rendered image for CHEMBL2377763
CHEMBL2377617
Rendered image for CHEMBL2377617
CHEMBL2377764
Rendered image for CHEMBL2377764
Protein-Protein Interactions (85)
FABP1
Tchem
Novelty:  0.00192691
Score:  0.961
Data Source:  STRINGDB
PPARA
Tclin
Family:  NR
Novelty:  0.00017403
Score:  0.946
Data Source:  STRINGDB
RXRA
Tclin
Family:  NR
Novelty:  0.00244343
Score:  0.917
Data Source:  STRINGDB
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
Score:  0.914
Data Source:  STRINGDB
CHD9
Tbio
Family:  Epigenetic
Novelty:  0.06234268
Score:  0.912
Data Source:  STRINGDB
SMARCD3
Tbio
Novelty:  0.03423481
Score:  0.904
Data Source:  STRINGDB
CARM1
Tchem
Family:  Epigenetic
Novelty:  0.00623937
Score:  0.903
Data Source:  STRINGDB
NCOA6
Tbio
Novelty:  0.00750424
Score:  0.902
Data Source:  STRINGDB
TBL1X
Tbio
Novelty:  0.00027212
Score:  0.9
Data Source:  STRINGDB
TGS1
Tbio
Family:  Enzyme
Novelty:  0.03390504
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (32)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
SLC-mediated transmembrane transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
86.1
leukocyte count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
86.1
leukocyte count
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 27 member 1
VGNC:12105
455841
Macaque
solute carrier family 27 member 1
719140
Mouse
MGI:1347098
26457
Rat
RGD:620927
94172
Dog
solute carrier family 27 member 1
VGNC:46329
484835
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 27 member 1
Macaque
solute carrier family 27 member 1
Mouse
Rat
Dog
solute carrier family 27 member 1
Publication Statistics
PubMed Score 136.31
PubMed score by year
PubTator Score 85.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title