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Tbio
LRRC8B
Volume-regulated anion channel subunit LRRC8B

Protein Summary
Description
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330947
  • ENSP00000332674
  • ENSG00000197147
  • ENST00000439853
  • ENSP00000400704
  • ENST00000639264
  • ENSP00000492151
  • ENST00000640258
  • ENSP00000491377

Symbol
  • KIAA0231
  • TALRRP
  • TA-LRRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
virus perturbation
0.83
histone modification site profile
0.8
transcription factor
0.78
microRNA
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.85   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.85   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
74.5
mean platelet volume
1
1
1
61
monocyte percentage of leukocytes
1
1
1
54.4
mathematical ability
2
2
2
34.7
blood protein measurement
1
1
1
3.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
74.5
mean platelet volume
1
61
monocyte percentage of leukocytes
1
54.4
mathematical ability
2
34.7
blood protein measurement
1
3.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 8 VRAC subunit B
VGNC:53228
738601
Macaque
leucine rich repeat containing 8 VRAC subunit B
100430724
Mouse
MGI:2141353
433926
Rat
RGD:1563429
305135
Dog
leucine rich repeat containing 8 VRAC subunit B
VGNC:42815
479958
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 8 VRAC subunit B
Macaque
leucine rich repeat containing 8 VRAC subunit B
Mouse
Rat
Dog
leucine rich repeat containing 8 VRAC subunit B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6P9F7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Miscellaneous transport and binding events (R-HSA-5223345)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Miscellaneous transport and binding events
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Miscellaneous transport and binding events
Transport of small molecules
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (63)
1 – 10 of 63
LRRC8D
Tbio
Novelty:  0.10536285
p_int:  0.999999984
p_ni:  1.1e-8
p_wrong:  5e-9
Score:  0.229
Data Source:  BioPlex,STRINGDB
LRRC8C
Tbio
Novelty:  0.11920205
p_int:  0.999999902
p_ni:  6.9e-8
p_wrong:  3e-8
Score:  0.196
Data Source:  BioPlex,STRINGDB
LRRC8A
Tbio
Novelty:  0.0163093
p_int:  0.999999606
p_ni:  3.93e-7
Score:  0.928
Data Source:  BioPlex,Reactome,STRINGDB
LRRC8E
Tbio
Novelty:  0.15689344
p_int:  0.999997116
p_ni:  0.000002884
Score:  0.187
Data Source:  BioPlex,STRINGDB
TSPAN3
Tbio
Novelty:  0.06362133
p_int:  0.998404003
p_ni:  0.001588558
p_wrong:  0.000007439
Data Source:  BioPlex
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.99818604
p_ni:  0.001813959
Score:  0.182
Data Source:  BioPlex,STRINGDB
SLC44A1
Tbio
Family:  Transporter
Novelty:  0.01499456
p_int:  0.998103858
p_ni:  0.000387843
p_wrong:  0.001508299
Score:  0.179
Data Source:  BioPlex,STRINGDB
ABCB9
Tbio
Family:  Transporter
Novelty:  0.02217672
p_int:  0.996862246
p_ni:  0.003137709
p_wrong:  4.5e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
TMEM164
Tdark
Novelty:  1.0284366
p_int:  0.996399811
p_ni:  0.003600189
Data Source:  BioPlex
ANO6
Tbio
Family:  IC
Novelty:  0.01288434
p_int:  0.981031341
p_ni:  0.018968659
Score:  0.212
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.85

PubMed score by year
PubTator Score  1.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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