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Tbio
CCDC62
Coiled-coil domain-containing protein 62

Protein Summary
Description
Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253079
  • ENSP00000253079
  • ENSG00000130783
  • ENST00000341952
  • ENSP00000341471
  • ENST00000392441
  • ENSP00000376236
  • ENST00000537566
  • ENSP00000445045

Symbol
  • CT109
  • ERAP75
  • TSP-NY
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
cell type or tissue
0.69
tissue sample
0.6
cellular component
0.54
cell line
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.36   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.36   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
7
7
98.2
BMI-adjusted waist-hip ratio
2
24
24
98.1
waist-hip ratio
1
23
23
98
waist circumference
1
17
17
96.3
BMI-adjusted waist circumference
1
15
15
93.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
98.2
BMI-adjusted waist-hip ratio
24
98.1
waist-hip ratio
23
98
waist circumference
17
96.3
BMI-adjusted waist circumference
15
93.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 62
VGNC:5322
452333
Macaque
coiled-coil domain containing 62
707179
Mouse
MGI:2684996
208908
Rat
RGD:1586391
689909
Dog
coiled-coil domain containing 62
VGNC:52925
102154299
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 62
Macaque
coiled-coil domain containing 62
Mouse
Rat
Dog
coiled-coil domain containing 62
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6P9F0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (61)
1 – 10 of 61
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.872
Data Source:  STRINGDB
MCCC1
Tbio
Family:  Enzyme
Novelty:  0.01234441
Score:  0.824
Data Source:  STRINGDB
ACMSD
Tchem
Family:  Enzyme
Novelty:  0.02825532
Score:  0.793
Data Source:  STRINGDB
HIP1R
Tbio
Novelty:  0.02502713
Score:  0.779
Data Source:  STRINGDB
STBD1
Tbio
Novelty:  0.08362185
Score:  0.773
Data Source:  STRINGDB
DGKQ
Tbio
Family:  Kinase
Novelty:  0.01973121
Score:  0.767
Data Source:  STRINGDB
GAK
Tchem
Family:  Kinase
Novelty:  0.00731928
Score:  0.743
Data Source:  STRINGDB
ESR2
Tclin
Family:  NR
Novelty:  0.0002362
Score:  0.742
Data Source:  STRINGDB
SYT11
Tbio
Novelty:  0.02472551
Score:  0.737
Data Source:  STRINGDB
STK39
Tchem
Family:  Kinase
Novelty:  0.00548476
Score:  0.728
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.36

PubMed score by year
PubTator Score  14.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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