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Tchem
NOTUM
Palmitoleoyl-protein carboxylesterase NOTUM

Protein Summary
Description
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409678
  • ENSP00000387310
  • ENSG00000185269

Symbol
  • hNOTUM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
kinase perturbation
0.76
transcription factor binding site profile
0.74
PubMedID
0.6
transcription factor
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.87   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.87   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 189
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0