NOTUM
Palmitoleoyl-protein carboxylesterase NOTUM
Protein Summary
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).
- ENST00000409678
- ENSP00000387310
- ENSG00000185269
- hNOTUM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.78 | ||
kinase perturbation | 0.76 | ||
transcription factor binding site profile | 0.74 | ||
PubMedID | 0.6 | ||
transcription factor | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 61.44 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 156 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 61.44 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 156 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 149
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (149)
Protein-Protein Interactions (167)
Nearest Tclin Targets
Pathways (75)
Reactome (8)
KEGG (1)
WikiPathways (66)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Hedgehog ligand biogenesis | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Post-translational protein phosphorylation | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Hedgehog ligand biogenesis | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Post-translational protein phosphorylation | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (2)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 2 | 5 | 6 | 76.5 | |||||
vital capacity | 1 | 1 | 1 | 73.2 | |||||
BMI-adjusted waist-hip ratio | 2 | 3 | 3 | 58.3 | |||||
birth weight | 2 | 2 | 2 | 55.2 | |||||
forced expiratory volume | 1 | 1 | 1 | 46.5 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 6 | 76.5 | |||||
vital capacity | 1 | 73.2 | |||||
BMI-adjusted waist-hip ratio | 3 | 58.3 | |||||
birth weight | 2 | 55.2 | |||||
forced expiratory volume | 1 | 46.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | notum, palmitoleoyl-protein carboxylesterase | VGNC:9485 | 100609059 | |||||
Mouse | MGI:1924833 | 77583 | ||||||
Rat | RGD:1307119 | 303743 | ||||||
Dog | notum, palmitoleoyl-protein carboxylesterase | VGNC:43901 | 483374 | |||||
Horse | notum, palmitoleoyl-protein carboxylesterase | VGNC:20820 | 100054869 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | notum, palmitoleoyl-protein carboxylesterase | |||||
Mouse | ||||||
Rat | ||||||
Dog | notum, palmitoleoyl-protein carboxylesterase | |||||
Horse | notum, palmitoleoyl-protein carboxylesterase | |||||
Publication Statistics
PubMed Score 61.44
PubMed score by year
PubTator Score 8.58
PubTator score by year
Related Publications
Text Mined References (7)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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