Tchem NOTUM Palmitoleoyl-protein carboxylesterase NOTUM

Protein Summary

Description

Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).

Uniprot Accession IDs

• Q6P988
• Q8N410
• Q8NI82

Gene Name

• NOTUM

Ensembl ID

• ENST00000409678
• ENSP00000387310
• ENSG00000185269

Symbol

• hNOTUM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.78
kinase perturbation	0.76
transcription factor binding site profile	0.74
PubMedID	0.6
transcription factor	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.87   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.87   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 189

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0