NOTUM
Palmitoleoyl-protein carboxylesterase NOTUM
Protein Summary
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).
- ENST00000409678
- ENSP00000387310
- ENSG00000185269
- hNOTUM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.78 | ||
kinase perturbation | 0.76 | ||
transcription factor binding site profile | 0.74 | ||
PubMedID | 0.6 | ||
transcription factor | 0.59 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.86 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 156 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.86 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 156 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 63
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (63)
1 – 10 of 63
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | notum, palmitoleoyl-protein carboxylesterase | VGNC:9485 | 100609059 | |||||
Mouse | MGI:1924833 | 77583 | ||||||
Rat | RGD:1307119 | 303743 | ||||||
Dog | notum, palmitoleoyl-protein carboxylesterase | VGNC:43901 | 483374 | |||||
Horse | notum, palmitoleoyl-protein carboxylesterase | VGNC:20820 | 100054869 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | notum, palmitoleoyl-protein carboxylesterase | |||||
Mouse | ||||||
Rat | ||||||
Dog | notum, palmitoleoyl-protein carboxylesterase | |||||
Horse | notum, palmitoleoyl-protein carboxylesterase | |||||
Protein Structure (12 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 12
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (75)
Reactome (8)
KEGG (1)
WikiPathways (66)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Hedgehog ligand biogenesis | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Post-translational protein phosphorylation | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Hedgehog ligand biogenesis | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Post-translational protein phosphorylation | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Gene Ontology Terms (10)
Functions (2)
Components (2)
Processes (6)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (167)
1 – 10 of 167
GPC3
Novelty: 0.00151823
Score: 0.976
Data Source: STRINGDB
WNT1
Novelty: 0.00124301
Score: 0.966
Data Source: STRINGDB
GPC5
Novelty: 0.01257358
Score: 0.962
Data Source: Reactome,STRINGDB
SHH
Novelty: 0.00028347
Score: 0.938
Data Source: Reactome,STRINGDB
BMP4
Novelty: 0.00047387
Score: 0.937
Data Source: STRINGDB
AHSG
Novelty: 0.00112502
Score: 0.932
Data Source: STRINGDB
ALB
Novelty: 0.00000616
Score: 0.932
Data Source: STRINGDB
IHH
Novelty: 0.00174847
Score: 0.928
Data Source: STRINGDB
AFP
Novelty: 0.00004755
Score: 0.928
Data Source: STRINGDB
DHH
Novelty: 0.00329784
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score 53.86
PubMed score by year
PubTator Score 8.58
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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