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Tbio
ALKBH5
RNA demethylase ALKBH5

Protein Summary
Description
Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399138
  • ENSP00000382091
  • ENSG00000091542

Symbol
  • ABH5
  • OFOXD1
  • ABH5
  • OFOXD
  • OFOXD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
virus perturbation
0.88
transcription factor perturbation
0.84
small molecule perturbation
0.75
transcription factor
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.31   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.31   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
2
2
81
sex hormone-binding globulin measurement
2
1
2
78.9
systolic blood pressure
1
1
1
72.9
BMI-adjusted waist-hip ratio
1
3
3
72.3
red blood cell density measurement
1
1
1
67.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
81
sex hormone-binding globulin measurement
2
78.9
systolic blood pressure
1
72.9
BMI-adjusted waist-hip ratio
3
72.3
red blood cell density measurement
1
67.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
alkB homolog 5, RNA demethylase
700205
Mouse
MGI:2144489
268420
Rat
RGD:1309496
303193
Dog
alkB homolog 5, RNA demethylase
VGNC:53262
609383
Horse
alkB homolog 5, RNA demethylase
VGNC:15257
100050716
Species
Name
OMA
EggNOG
Inparanoid
Macaque
alkB homolog 5, RNA demethylase
Mouse
Rat
Dog
alkB homolog 5, RNA demethylase
Horse
alkB homolog 5, RNA demethylase
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6P6C2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
DNA Damage Reversal (R-HSA-73942)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Reversal
Reactome
DNA Repair
Reactome
Reversal of alkylation damage by DNA dioxygenases
Name
Explore in Pharos
Explore in Source
DNA Damage Reversal
DNA Repair
Reversal of alkylation damage by DNA dioxygenases
Gene Ontology Terms (16)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (48)
1 – 10 of 48
METTL14
Tbio
Family:  Enzyme
Novelty:  0.01377112
Score:  0.932
Data Source:  STRINGDB
FTO
Tchem
Family:  Enzyme
Novelty:  0.00053473
Score:  0.93
Data Source:  STRINGDB
WTAP
Tbio
Novelty:  0.01491546
Score:  0.915
Data Source:  STRINGDB
YTHDF2
Tbio
Novelty:  0.01498605
Score:  0.914
Data Source:  STRINGDB
ALKBH1
Tbio
Family:  Enzyme
Novelty:  0.00504781
Score:  0.902
Data Source:  STRINGDB
JMJD4
Tbio
Novelty:  0.09951585
Score:  0.9
Data Source:  STRINGDB
METTL3
Tbio
Family:  Enzyme
Novelty:  0.00420954
Score:  0.873
Data Source:  STRINGDB
YTHDF1
Tbio
Novelty:  0.02063275
Score:  0.841
Data Source:  STRINGDB
ALKBH2
Tbio
Family:  Enzyme
Novelty:  0.02318716
Score:  0.795
Data Source:  STRINGDB
YTHDC1
Tbio
Novelty:  0.0156474
Score:  0.795
Data Source:  STRINGDB
Publication Statistics
PubMed Score  120.31

PubMed score by year
PubTator Score  22.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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