You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PKN3
Serine/threonine-protein kinase N3

Protein Classes
Protein Summary
Description
Contributes to invasiveness in malignant prostate cancer.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291906
  • ENSP00000291906
  • ENSG00000160447

Symbol
  • PKNBETA
  • UTDP4-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.93
histone modification site profile
0.74
transcription factor
0.68
tissue sample
0.57


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.34   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.34   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
1
6
97.4
myeloid white cell count
1
1
1
72.1
neutrophil count
2
1
2
72.1
platelet crit
2
2
2
66.5
low density lipoprotein cholesterol measurement
2
1
2
50.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
97.4
myeloid white cell count
1
72.1
neutrophil count
2
72.1
platelet crit
2
66.5
low density lipoprotein cholesterol measurement
2
50.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase N3
VGNC:4822
464773
Macaque
protein kinase N3
717319
Mouse
MGI:2388285
263803
Dog
protein kinase N3
VGNC:44613
491313
Horse
protein kinase N3
VGNC:21499
100066882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase N3
Macaque
protein kinase N3
Mouse
Dog
protein kinase N3
Horse
protein kinase N3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6P5Z2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (55)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases activate PKNs
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases activate PKNs
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (60)
1 – 10 of 60
IFT20
Tbio
Novelty: 0.03005088
p_int: 0.999995999
p_ni: 0.000004001
Data Source: BioPlex
NUP62
Tbio
Novelty: 0.01432724
p_int: 0.999976108
p_ni: 0.000023892
Data Source: BioPlex
SKAP1
Tbio
Family: Enzyme
Novelty: 0.03753848
p_int: 0.999949398
p_ni: 0.000050602
Data Source: BioPlex
DEF8
Tdark
Novelty: 0.21146806
p_int: 0.99994811
p_ni: 0.00005189
Data Source: BioPlex
PTGER3
Tclin
Family: GPCR
Novelty: 0.0012681
p_int: 0.999850164
p_ni: 0.000149836
Data Source: BioPlex
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
p_int: 0.999801269
p_ni: 0.000198731
Data Source: BioPlex
HAVCR2
Tbio
Novelty: 0.00155885
p_int: 0.999709151
p_ni: 0.000290849
Score: 0.163
Data Source: BioPlex,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
p_int: 0.999470313
p_ni: 0.000529687
Score: 0.997
Data Source: BioPlex,STRINGDB
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.995735525
p_ni: 0.004263251
p_wrong: 0.000001223
Data Source: BioPlex
EFNB3
Tbio
Novelty: 0.0120367
p_int: 0.993635099
p_ni: 0.005756082
p_wrong: 0.000608819
Data Source: BioPlex
Publication Statistics
PubMed Score  21.34

PubMed score by year
PubTator Score  11.48

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: