Pharos: Illuminating the Druggable Genome

Tdark

Protein Summary

Uniprot Accession IDs

Gene Name

C22orf39

Ensembl ID

ENST00000399562
ENSP00000382474
ENSG00000242259
ENST00000542103
ENSP00000439212
ENST00000611555
ENSP00000479673

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0

biological term	0

cell line	0

cell type or tissue	0

cellular component	0

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.13 (req: < 5)

View Publications

Gene RIFs: 0 (req: <= 3)

Antibodies: 9 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.13 (req: >= 5)

Gene RIFs: 0 (req: > 3)

Antibodies: 9 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (5)

WikiPathways (5)

Items per page:

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	22q11.2 Deletion Syndrome	389 targets	WP4657_r105133

WikiPathways	22q11.2 Deletion Syndrome	389 targets	WP4657_r105133

WikiPathways	22q11.2 Deletion Syndrome	389 targets	WP4657_r105133

WikiPathways	22q11.2 Deletion Syndrome	389 targets	WP4657_r105133

WikiPathways	Fragile X Syndrome	1471 targets	WP4549_r104796

Name	Explore in Pharos	Explore in Source
22q11.2 Deletion Syndrome	389 targets	WP4657_r105133

22q11.2 Deletion Syndrome	389 targets	WP4657_r105133

22q11.2 Deletion Syndrome	389 targets	WP4657_r105133

22q11.2 Deletion Syndrome	389 targets	WP4657_r105133

Fragile X Syndrome	1471 targets	WP4549_r104796

Protein-Protein Interactions (19)

1 – 10 of 19

See Interactions on String-DB

TIMM8A

Tbio

Family: Enzyme

Novelty: 0.00261956

p_int: 0.999987182

p_ni: 0.000004612

p_wrong: 0.000008206

Data Source: BioPlex

ATP23

Tbio

Family: Enzyme

Novelty: 0.13977877

p_int: 0.99996885

p_ni: 0.000001031

p_wrong: 0.000030119

Data Source: BioPlex

ECM1

Tbio

Novelty: 0.00696614

p_int: 0.995790801

p_ni: 7.14e-7

p_wrong: 0.004208484

Data Source: BioPlex

TRIM74

Tdark

Novelty: 5

Score: 0.659

Data Source: STRINGDB

TRIM73

Tdark

Novelty: 1.11111111

Score: 0.641

Data Source: STRINGDB

ANKRD36

Tdark

Novelty: 1.10032362

Score: 0.553

Data Source: STRINGDB

ZNF74

Tbio

Family: TF

Novelty: 0.14162077

Score: 0.511

Data Source: STRINGDB

MRPS33

Tdark

Novelty: 0.4

Score: 0.507

Data Source: STRINGDB

TRIM50

Tbio

Family: Enzyme

Novelty: 0.25641026

Score: 0.493

Data Source: STRINGDB

NRROS

Tbio

Novelty: 0.15009747

Score: 0.491

Data Source: STRINGDB

Publication Statistics

PubMed Score 0.13

PubMed score by year

Amino Acid Sequence

Residue Counts

Sequence

MCRCSLVLLSVDHEVPFSSFFIGWRTEGRAWRAGRPDMADGSGWQPPRPCEAYRAEWKLCRSARHFLHHY

1-70

YVHGERPACEQWQRDLASCRDWEERRNAEAQQSLCESERARVRAARKHILVWAPRQSPPPDWHLPLPQEK

70-140

140-142

MCRCSLVLLSVDHEVPFSSFFIGWRTEGRAWRAGRPDMADGSGWQPPRPCEAYRAEWKLCRSARHFLHHYYVHGERPACEQWQRDLASCRDWEERRNAEAQQSLCESERARVRAARKHILVWAPRQSPPPDWHLPLPQEKDE

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