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Tbio
SLC39A4
Zinc transporter ZIP4

Protein Summary
Description
Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity). This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276833
  • ENSP00000276833
  • ENSG00000147804
  • ENST00000301305
  • ENSP00000301305

Symbol
  • ZIP4
  • AEZ
  • ZIP4
  • AWMS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.86
cellular component
0.83
gene perturbation
0.77
transcription factor perturbation
0.74
cell type or tissue
0.72


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.14   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.14   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 39 member 4
708333
Mouse
MGI:1919277
72027
Rat
RGD:1306701
300051
Dog
solute carrier family 39 member 4
VGNC:46404
482096
Horse
solute carrier family 39 member 4
VGNC:23204
100147065
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 39 member 4
Mouse
Rat
Dog
solute carrier family 39 member 4
Horse
solute carrier family 39 member 4
Pathways (15)
Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) (R-HSA-5619088)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Metal ion SLC transporters
Reactome
SLC transporter disorders
Name
Explore in Pharos
Explore in Source
Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)
Disease
Disorders of transmembrane transporters
Metal ion SLC transporters
SLC transporter disorders
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CACAO
Protein-Protein Interactions (117)
1 – 10 of 117
GOLM1
Tbio
Novelty: 0.00752112
p_int: 0.999998532
p_ni: 0.000001468
Data Source: BioPlex
TMEM143
Tdark
Novelty: 1.58941369
p_int: 0.999994896
p_ni: 0.000005072
p_wrong: 3.2e-8
Data Source: BioPlex
LETMD1
Tbio
Novelty: 0.02790517
p_int: 0.999994356
p_ni: 0.000005643
Data Source: BioPlex
ABCD1
Tbio
Family: Transporter
Novelty: 0.0067013
p_int: 0.999815311
p_ni: 0.000183731
p_wrong: 9.58e-7
Data Source: BioPlex
PTPN2
Tchem
Family: Enzyme
Novelty: 0.00372891
p_int: 0.999813723
p_ni: 0.000173269
p_wrong: 0.000013007
Data Source: BioPlex
PIGW
Tbio
Novelty: 0.0245774
p_int: 0.999792387
p_ni: 0.000207613
Data Source: BioPlex
S1PR5
Tclin
Family: GPCR
Novelty: 0.01032055
p_int: 0.999403233
p_ni: 0.000027462
p_wrong: 0.000569305
Data Source: BioPlex
TMEM120B
Tdark
Novelty: 1.46242586
p_int: 0.999068301
p_ni: 0.000931409
p_wrong: 2.9e-7
Data Source: BioPlex
ELOVL2
Tbio
Novelty: 0.00665823
p_int: 0.998731962
p_ni: 0.001214683
p_wrong: 0.000053355
Score: 0.165
Data Source: BioPlex,STRINGDB
FZD7
Tbio
Family: GPCR
Novelty: 0.00916448
p_int: 0.998726911
p_ni: 0.000154963
p_wrong: 0.001118126
Data Source: BioPlex
Publication Statistics
PubMed Score  147.14

PubMed score by year
PubTator Score  84.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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