You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KLC3
Kinesin light chain 3

Protein Summary
Description
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391946
  • ENSP00000375810
  • ENSG00000104892
  • ENST00000470402
  • ENSP00000436019
  • ENST00000585434
  • ENSP00000466067

Symbol
  • KLC2
  • KLC2L
  • KLC2
  • KLCt
  • KLC2L
  • KNS2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cellular component
0.71
molecular function
0.6
cell line
0.56
gene perturbation
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.35   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.35   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (176)
1 – 10 of 176
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.99999999
p_ni:  8e-9
p_wrong:  2e-9
Score:  0.737
Data Source:  BioPlex,STRINGDB
MYCL
Tbio
Family:  TF
Novelty:  0.0034508
p_int:  0.99999996
p_ni:  1.1e-8
p_wrong:  2.9e-8
Score:  0.625
Data Source:  BioPlex,STRINGDB
KLC1
Tbio
Novelty:  0.00653484
p_int:  0.999999921
p_ni:  7.8e-8
p_wrong:  2e-9
Score:  0.982
Data Source:  BioPlex,STRINGDB
KIF5B
Tbio
Novelty:  0.00515256
Score:  0.983
Data Source:  STRINGDB
KIF5A
Tbio
Novelty:  0.01277095
Score:  0.978
Data Source:  STRINGDB
KLC2
Tbio
Novelty:  0.06284367
Score:  0.971
Data Source:  STRINGDB
KIF1A
Tbio
Novelty:  0.00505209
Score:  0.949
Data Source:  STRINGDB
KIF1B
Tbio
Novelty:  0.00984332
Score:  0.943
Data Source:  STRINGDB
DYNC1LI2
Tbio
Novelty:  0.17381295
Score:  0.935
Data Source:  STRINGDB
KIFAP3
Tbio
Novelty:  0.01902437
Score:  0.934
Data Source:  STRINGDB
Pathways (17)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
4
4
7
98.4
platelet count
3
4
3
2.6
96.9
monocyte count
2
2
2
95.8
neutrophil count
3
2
3
95.1
leukocyte count
2
2
2
95
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
7
98.4
platelet count
3
2.6
96.9
monocyte count
2
95.8
neutrophil count
3
95.1
leukocyte count
2
95
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin light chain 3
VGNC:2332
468918
Macaque
kinesin light chain 3
714331
Mouse
MGI:1277971
232943
Rat
RGD:621432
171549
Dog
kinesin light chain 3
VGNC:42428
484448
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin light chain 3
Macaque
kinesin light chain 3
Mouse
Rat
Dog
kinesin light chain 3
Publication Statistics
PubMed Score 22.35
PubMed score by year
PubTator Score 2.24
PubTator score by year