Tbio TNFAIP8L2 Tumor necrosis factor alpha-induced protein 8-like protein 2

Protein Summary

Description

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).

Uniprot Accession IDs

• Q6P589
• Q6I9Y0
• Q9H2H7
• Q9H5G2
• TIPE2

Gene Name

• TNFAIP8L2

Ensembl ID

• ENST00000368910
• ENSP00000357906
• ENSG00000163154

Symbol

• TIPE2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.92
tissue sample	0.69
PubMedID	0.55
cell type or tissue	0.54
tissue	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.05   (req: < 5)

Gene RIFs: 71   (req: <= 3)

Antibodies: 136   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.05   (req: >= 5)

Gene RIFs: 71   (req: > 3)

Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0