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Tbio
TNFAIP8L2
Tumor necrosis factor alpha-induced protein 8-like protein 2

Protein Summary
Description
Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368910
  • ENSP00000357906
  • ENSG00000163154

Symbol
  • TIPE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.92
tissue sample
0.69
PubMedID
0.55
cell type or tissue
0.54
tissue
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.49   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.49   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
33.3
78.9
1
1
0
100
76.6
monocyte percentage of leukocytes
1
1
1
60.5
vitamin D measurement
1
1
1
59
body height
2
2
2
55.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
33.3
78.9
0
100
76.6
monocyte percentage of leukocytes
1
60.5
vitamin D measurement
1
59
body height
2
55.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF alpha induced protein 8 like 2
VGNC:7010
100614116
Macaque
TNF alpha induced protein 8 like 2
709632
Mouse
MGI:1917019
69769
Rat
RGD:1310519
310663
Dog
TNF alpha induced protein 8 like 2
VGNC:47653
483192
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF alpha induced protein 8 like 2
Macaque
TNF alpha induced protein 8 like 2
Mouse
Rat
Dog
TNF alpha induced protein 8 like 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6P589-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (40)
1 – 10 of 40
TES
Tbio
Novelty:  0.00052221
p_int:  0.99500459
p_ni:  0.004995409
p_wrong:  2e-9
Score:  0.513
Data Source:  BioPlex,STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.711
Data Source:  STRINGDB
FBXW5
Tbio
Novelty:  0.13100873
Score:  0.698
Data Source:  STRINGDB
S1PR4
Tclin
Family:  GPCR
Novelty:  0.01523676
Score:  0.677
Data Source:  STRINGDB
POMP
Tbio
Novelty:  0.01885028
Score:  0.631
Data Source:  STRINGDB
LILRB2
Tbio
Novelty:  0.00545569
Score:  0.631
Data Source:  STRINGDB
IGSF6
Tbio
Novelty:  0.05015035
Score:  0.624
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.584
Data Source:  STRINGDB
SCNM1
Tbio
Novelty:  0.19700548
Score:  0.569
Data Source:  STRINGDB
HCST
Tbio
Novelty:  0.01604587
Score:  0.56
Data Source:  STRINGDB
Publication Statistics
PubMed Score  103.49

PubMed score by year
PubTator Score  43.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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